INT268359

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.76
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (MLH1) nucleus (MLH1) cell cycle (MLH1)
MLH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 1 12.00 Low Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colorectal Cancer 50 97.60 Very High Very High Very High
Cancer 31 83.40 Quite High
Aging 1 82.24 Quite High
Carcinoma 16 26.12 Quite Low
Hereditary Nonpolyposis Colorectal Neoplasms 11 17.80 Low Low
Colon Cancer 4 5.16 Low Low
Familial Adenomatous Polyposis 48 5.00 Very Low Very Low Very Low
Syndrome 38 5.00 Very Low Very Low Very Low
Polyps 35 5.00 Very Low Very Low Very Low
Adenoma 33 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They found in cell lines that were CIMP+ there was widespread silencing of genes through promoter methylation which they hypothesised could also cause inactivation of the hMLH1 promoter and thus may play a role in up to 75% of sporadic colorectal carcinoma cases that are MSI+.
Positive_regulation (inactivation) of hMLH1 associated with colorectal cancer
1) Confidence 0.12 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.76 Pain Relevance 0

General Comments

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