INT268360

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Context Info
Confidence 0.55
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.55
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (SMAD4) intracellular (SMAD4) protein binding transcription factor activity (SMAD4)
DNA binding (SMAD4) cytoplasm (SMAD4) cytosol (SMAD4)
SMAD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 13 60.08 Quite High
cINOD 7 5.00 Very Low Very Low Very Low
COX2 5 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colorectal Cancer 100 99.16 Very High Very High Very High
Hyperplasia 30 92.24 High High
Cancer 70 89.04 High High
Colon Cancer 34 83.64 Quite High
Apoptosis 11 82.00 Quite High
Pancreatic Cancer 2 70.32 Quite High
Stress 2 64.44 Quite High
Hypoxia 1 64.16 Quite High
Metastasis 4 62.88 Quite High
Malignant Neoplastic Disease 17 52.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A study by Zhou et al. [106] took human colorectal cancer cell lines and used targeted deletion to inactivate the SMAD4 gene.
Positive_regulation (inactivate) of SMAD4 associated with colorectal cancer
1) Confidence 0.55 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.68 Pain Relevance 0
The upregulation of WIF1, SMAD4 and TLE1 would be expected to counteract ?
Positive_regulation (upregulation) of SMAD4
2) Confidence 0.47 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721360 Disease Relevance 0.32 Pain Relevance 0.03
This causes phosphorylation of SMAD2 and SMAD3, two transcription factors that then bind to and activate SMAD4.
Positive_regulation (activate) of SMAD4
3) Confidence 0.39 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.55 Pain Relevance 0

General Comments

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