INT268377

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Context Info
Confidence 0.80
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0.85
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SMAD2) nucleoplasm (SMAD2) nucleus (SMAD2)
intracellular (SMAD2) DNA binding (SMAD2) transcription factor binding (SMAD2)
Anatomy Link Frequency
quadriceps 1
satellite cells 1
SMAD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 100 95.88 Very High Very High Very High
long-term potentiation 7 76.52 Quite High
nMDA receptor 2 70.24 Quite High
addiction 1 46.28 Quite Low
ketamine 12 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 21 89.56 High High
Cancer 36 87.64 High High
Hypertrophy 72 77.04 Quite High
Pancreatic Cancer 1 73.68 Quite High
Colorectal Cancer 50 63.52 Quite High
Familial Adenomatous Polyposis 48 42.88 Quite Low
Lifespan 8 39.44 Quite Low
Hyperplasia 51 37.36 Quite Low
Necrosis 1 34.88 Quite Low
Adenoma 33 31.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When the biologically active form of myostatin engages the activin IIB receptor an intracellular signaling cascade results in phosphorylation of Smad 2/3.
Phosphorylation (phosphorylation) of Smad 2
1) Confidence 0.80 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0 Pain Relevance 0
In C57 Bl/6 mice overexpressing dnMstat there was a decrease in the levels of phosphorylated Smad 2/3 as was seen in C2C12 cells incubated with anti-myostatin antibody [3].
Phosphorylation (phosphorylated) of Smad 2
2) Confidence 0.80 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0.08 Pain Relevance 0
Phosphorylated Smad 2/3 then translocates to the nucleus to suppress expression of myogenic factors and cell cycle progression in satellite cells.
Phosphorylation (Phosphorylated) of Smad 2 in satellite cells
3) Confidence 0.80 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0 Pain Relevance 0
In treated quadriceps there was a decrease in phosphorylated Smad 2/3, a decrease in phosphorylated JNK and an increase in phosphorylated Akt (n?
Phosphorylation (phosphorylated) of Smad 2 in quadriceps
4) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820101 Disease Relevance 0 Pain Relevance 0
It phosphorylates smad2/3, which consequently binds with smad4 to form an antitumorigenesis transcription factor.
Phosphorylation (phosphorylates) of smad2
5) Confidence 0.61 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC2944280 Disease Relevance 0 Pain Relevance 0.17
This causes phosphorylation of SMAD2 and SMAD3, two transcription factors that then bind to and activate SMAD4.
Phosphorylation (phosphorylation) of SMAD2
6) Confidence 0.61 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.60 Pain Relevance 0
Subcellular location of phosphorylated Smad2 (PSmad2) protein was assessed by confocal microscopy (Figure 3, panel B).
Phosphorylation (phosphorylated) of Smad2
7) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842433 Disease Relevance 0.17 Pain Relevance 0.48

General Comments

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