INT268379

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Context Info
Confidence 0.16
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 22
Total Number 23
Disease Relevance 9.34
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ARAF) protein modification process (ARAF) mitochondrion (ARAF)
cellular_component (ARAF)
Anatomy Link Frequency
myometrium 1
longitudinal muscle 1
uterus 1
testis 1
adrenal glands 1
ARAF (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 57 99.16 Very High Very High Very High
Inflammation 18 93.72 High High
Inflammatory response 9 89.12 High High
Intracerebroventricular 9 83.84 Quite High
IPN 9 81.60 Quite High
Pain 10 77.76 Quite High
Neuropathic pain 8 43.80 Quite Low
Migraine 8 42.96 Quite Low
addiction 8 41.68 Quite Low
Central nervous system 9 21.04 Low Low
Disease Link Frequency Relevance Heat
Cancer 333 98.72 Very High Very High Very High
Hematological Disease 36 96.24 Very High Very High Very High
Viral Infection 9 95.56 Very High Very High Very High
INFLAMMATION 30 93.72 High High
Hyperplasia 68 93.68 High High
Prostate Cancer 27 92.80 High High
Infection 15 90.28 High High
Stress 5 89.72 High High
Glioma 48 87.84 High High
Chromosomal Instability 6 86.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In their model, it was suggested that mutation of the k-ras proto-oncogene leading to activation of the oncogene as well as mutational inactivation of tumour suppressor genes existing on chromosomes 5q (APC), 7p (p53) and 18q (SMAD4) were the key initiators of colorectal carcinogenesis.
Gene_expression (mutation) of oncogene associated with cancer
1) Confidence 0.16 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.39 Pain Relevance 0
In their model, it was suggested that mutation of the k-ras proto-oncogene leading to activation of the oncogene as well as mutational inactivation of tumour suppressor genes existing on chromosomes 5q (APC), 7p (p53) and 18q (SMAD4) were the key initiators of colorectal carcinogenesis.
Gene_expression (proto) of oncogene associated with cancer
2) Confidence 0.16 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.28 Pain Relevance 0
These Hsp90 clients comprise kinases such as ERBB2, EGFR, CDK4, RAF, AKT, cMET and BCR-ABL, and transcription factors such as HIF-1?
Gene_expression (kinases) of RAF
3) Confidence 0.12 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.75 Pain Relevance 0
Furthermore, cells express up to three Raf types (i.e., A-, B- and c-Raf), which are affected differently by upstream targets, thereby adding a further level of complexity to MAPK-mediated signaling [13,14].
Gene_expression (express) of Raf
4) Confidence 0.07 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0.49 Pain Relevance 0.12
Consequently, cell type-specific effects of VPA on the degree of Erk1/2 phosphorylation may be partially explained by cell type-specific differences in the expression of Raf isoforms.
Gene_expression (expression) of Raf
5) Confidence 0.07 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0.06 Pain Relevance 0.05
, in a manner similar to other ectopically expressed signaling molecules, such as AKT, RAF or PI3-kinase [29], [30], [31] (Fig. 6A).
Gene_expression (expressed) of RAF
6) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813871 Disease Relevance 0.23 Pain Relevance 0
An analysis of Raf expression revealed that all three Raf isoforms were expressed in all 10 investigated cell lines, although at highly variable levels (Additional file 1, Figure S3).
Gene_expression (expressed) of Raf
7) Confidence 0.05 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0.07 Pain Relevance 0.05
However, the analysis of Raf expression did not include studies of Raf mutations, and therefore the possibility that the expression of mutated Raf isoforms can contribute to the observed results cannot be excluded.
Gene_expression (expression) of Raf
8) Confidence 0.05 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0.39 Pain Relevance 0.03
However, no apparent relationship was found between the expression of the respective Raf isoforms and the observed changes in the degree of Erk1/2 phosphorylation in response to VPA.
Gene_expression (expression) of Raf
9) Confidence 0.05 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0.20 Pain Relevance 0.04
However, the analysis of Raf expression did not include studies of Raf mutations, and therefore the possibility that the expression of mutated Raf isoforms can contribute to the observed results cannot be excluded.
Gene_expression (expression) of Raf
10) Confidence 0.05 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0.36 Pain Relevance 0.04
An analysis of Raf expression revealed that all three Raf isoforms were expressed in all 10 investigated cell lines, although at highly variable levels (Additional file 1, Figure S3).
Gene_expression (expression) of Raf
11) Confidence 0.05 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0.07 Pain Relevance 0.05
Furthermore, cells express up to three Raf types (i.e., A-, B- and c-Raf), which are affected differently by upstream targets, thereby adding a further level of complexity to MAPK-mediated signaling [13,14].
Gene_expression (express) of Raf
12) Confidence 0.04 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0.49 Pain Relevance 0.12
Gao et al. observed above-additive tumor growth rates in castrated and mock nude male mice upon the forced expression of constitutively active Akt and B-Raf [65].
Gene_expression (expression) of Raf associated with cancer
13) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0.42 Pain Relevance 0
Similarly, no studies have investigated the expression of PKs or their receptors in first trimester decidua or myometrium, or in the second trimester fetoplacental unit.
Spec (investigated) Gene_expression (expression) of PKs in myometrium
14) Confidence 0.04 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.22 Pain Relevance 0
PKs were initially reported to be expressed in the gastrointestinal tract, where they were shown directly to stimulate contraction of the ileum longitudinal muscle of guinea pigs [1].
Gene_expression (expressed) of PKs in longitudinal muscle
15) Confidence 0.04 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.07 Pain Relevance 0.04
The expression of PKs and their receptors has been reported in the prostate [1,14,38].
Gene_expression (expression) of PKs
16) Confidence 0.04 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.46 Pain Relevance 0.09
PKs and their receptors are expressed in the ovary, uterus and in various tissues of pregnancy [21,23,39].
Gene_expression (expressed) of PKs in uterus
17) Confidence 0.04 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.41 Pain Relevance 0.08
PKs are also expressed in steroidogenic tissues, including the testis [8,20], ovary [21,22], placenta [2,23] and adrenal glands [17].
Gene_expression (expressed) of PKs in adrenal glands
18) Confidence 0.04 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.06 Pain Relevance 0.03
PKs and their receptors are expressed in the testis and the prostate.
Gene_expression (expressed) of PKs in testis
19) Confidence 0.04 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.67 Pain Relevance 0.20
Role of PKs in pathologies of the reproductive tract
Gene_expression (Role) of PKs in reproductive tract
20) Confidence 0.03 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0.78 Pain Relevance 0

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