INT268380

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 3.49
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ARAF) protein modification process (ARAF) mitochondrion (ARAF)
cellular_component (ARAF)
ARAF (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 6 89.16 High High
Neuropathic pain 1 59.28 Quite High
Migraine 1 58.44 Quite High
cytokine 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 70 99.96 Very High Very High Very High
Cancer 77 98.44 Very High Very High Very High
Fatigue 2 89.40 High High
Pressure And Volume Under Development 2 88.92 High High
Neutropenia 1 88.24 High High
Disease 9 86.56 High High
Chromosomal Instability 3 85.32 High High
Lung Cancer 2 83.84 Quite High
Colorectal Cancer 50 82.96 Quite High
Apoptosis 11 82.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In their model, it was suggested that mutation of the k-ras proto-oncogene leading to activation of the oncogene as well as mutational inactivation of tumour suppressor genes existing on chromosomes 5q (APC), 7p (p53) and 18q (SMAD4) were the key initiators of colorectal carcinogenesis.
Positive_regulation (leading) of Positive_regulation (activation) of oncogene associated with cancer
1) Confidence 0.12 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.29 Pain Relevance 0
The Ras oncogene is mutated in about 90% of pancreatic cancers, leading to constitutive activation of the Ras-Raf-MAPK signal transduction pathway.
Positive_regulation (leading) of Positive_regulation (activation) of Ras-Raf-MAPK associated with pancreatic cancer
2) Confidence 0.07 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727890 Disease Relevance 1.22 Pain Relevance 0
Signaling through this pathway is often initiated by activation of membrane-localized receptors, leading to activation of the GTPase Ras, and subsequent activation of the MAPK kinase kinase Raf, the MAPK kinases MEK1/2 and the MAPKs Erk1/2 [11].
Positive_regulation (leading) of Positive_regulation (activation) of Raf
3) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2918577 Disease Relevance 0.98 Pain Relevance 0.25

General Comments

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