INT268386
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
In their model, it was suggested that mutation of the k-ras proto-oncogene leading to activation of the oncogene as well as mutational inactivation of tumour suppressor genes existing on chromosomes 5q (APC), 7p (p53) and 18q (SMAD4) were the key initiators of colorectal carcinogenesis. | |||||||||||||||
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The Ras oncogene is mutated in about 90% of pancreatic cancers, leading to constitutive activation of the Ras-Raf-MAPK signal transduction pathway. | |||||||||||||||
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Signaling through this pathway is often initiated by activation of membrane-localized receptors, leading to activation of the GTPase Ras, and subsequent activation of the MAPK kinase kinase Raf, the MAPK kinases MEK1/2 and the MAPKs Erk1/2 [11]. | |||||||||||||||
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Perturbation of Raf, MEK or ERK had similar effects on the functional markers with ERK being the most notable (Fig. 8, lanes 1, 2 and 3). | |||||||||||||||
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Hypoxia/DHP-d can activate ERK MAPKs via pathways independent or dependent [30] of Ras and Raf activation. | |||||||||||||||
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Additionally, it has been proposed that PKs potentially function as mediators of the inflammatory response during testicular infections [20]. | |||||||||||||||
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General Comments
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