INT268389

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.62
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TGFBR2)
TGFBR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 1 99.90 Very High Very High Very High
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 31 96.86 Very High Very High Very High
Colorectal Cancer 50 83.12 Quite High
Aging 1 36.88 Quite Low
Familial Adenomatous Polyposis 48 5.00 Very Low Very Low Very Low
Syndrome 38 5.00 Very Low Very Low Very Low
Polyps 35 5.00 Very Low Very Low Very Low
Adenoma 33 5.00 Very Low Very Low Very Low
Carcinoma 16 5.00 Very Low Very Low Very Low
Hyperplasia 15 5.00 Very Low Very Low Very Low
Hereditary Nonpolyposis Colorectal Neoplasms 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In tumours where 4/5 of the CIMP panel were hypermethylated, they found a decrease in the expression of nuclear p27 and p53, as well as reduced expression of COX2 and increased TGFBR2 mutations.
Positive_regulation (increased) of TGFBR2 associated with cancer and cox2
1) Confidence 0.39 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 0.62 Pain Relevance 0.05

General Comments

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