INT268395

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.21
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (APC, Kras) mitochondrion (Kras) GTPase activity (Kras)
protein complex assembly (APC) cytoplasm (APC) cytosol (APC)
APC (Homo sapiens)
Kras (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 48 100.00 Very High Very High Very High
Polyps 35 98.20 Very High Very High Very High
Hyperplasia 15 94.12 High High
Adenoma 33 91.32 High High
Carcinoma 16 85.04 High High
Colorectal Cancer 50 66.72 Quite High
Apoptosis 5 52.00 Quite High
Aneuploidy 2 31.76 Quite Low
Chromosome Aberrations 1 23.36 Low Low
Syndrome 38 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In both groups of polyps there was approximately a 22-25% rate of k-ras mutation but in dysplastic lesions this k-ras mutation was always associated with an APC mutation, suggesting that k-ras mutations may be insufficient on their own to initiate carcinogenesis.
APC Binding (associated) of ras associated with familial adenomatous polyposis and polyps
1) Confidence 0.04 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.21 Pain Relevance 0

General Comments

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