INT268403

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.22
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (SCAP) aging (SCAP) Golgi apparatus (SCAP)
endoplasmic reticulum (SCAP) protein complex (SCAP)
SCAP (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 1 72.00 Quite High
peripheral neuropathy 13 5.00 Very Low Very Low Very Low
dexamethasone 10 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Duloxetine 1 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
Gabapentin 1 5.00 Very Low Very Low Very Low
vincristine 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 7 99.08 Very High Very High Very High
Apoptosis 12 95.44 Very High Very High Very High
Disease 11 82.16 Quite High
Syndrome 6 81.20 Quite High
Cystic Fibrosis 1 72.56 Quite High
Thrombocytopenia 5 70.40 Quite High
Cancer 34 50.00 Quite Low
Celiac Disease 1 44.56 Quite Low
Ulcers 2 29.28 Quite Low
Gastritis 4 27.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Besides the above stress-markers, decrease of secretory IgA [87], and increase [36] of immune-modulator defense protein salivary chaperone Hsp70 [35, 38] was also reported.
Positive_regulation (increase) of chaperone associated with stress
1) Confidence 0.01 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674305 Disease Relevance 0.90 Pain Relevance 0.04
Once the UPR is activated, the unfolded proteins are refolded by upregulation of the chaperone molecules or destroyed through cytosolic 26S proteasomes; otherwise, accumulation of unfolded protein results in apoptosis of the cell (Figure 9).
Positive_regulation (upregulation) of chaperone associated with apoptosis
2) Confidence 0.01 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2990320 Disease Relevance 0.32 Pain Relevance 0

General Comments

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