INT268438

Context Info Confidence 0.14 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.49 Pain Relevance 0

cell proliferation (Lipa) cell morphogenesis (Lipa) lipid metabolic process (Lipa) lysosome (Lipa)

Anatomy Link Frequency plaques 2 Lipa (Mus musculus)

Pain Link Frequency Relevance Heat Bile 1 34.84 Inflammation 6 5.00 Central nervous system 4 5.00 tolerance 2 5.00 Enkephalin 1 5.00 Inflammatory response 1 5.00 metalloproteinase 1 5.00 Hippocampus 1 5.00 cva 1 5.00 substance P 1 5.00

Disease Link Frequency Relevance Heat Atherosclerotic Plaque 5 99.48 Atherosclerosis 17 88.16 Disease 40 62.08 Neurodegenerative Disease 1 58.08 Dementia 1 50.00 Toxicity 6 32.12 Amyloid Plaque 4 20.32 Alzheimer's Dementia 5 16.24 Age-related Macular Degeneration 10 5.00 Ocular Toxicity (including Many Sub-types) 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In fact, exogenous supplementation with lysosomal acid lipase was previously shown to reduce the size of atherosclerotic plaques in mice [83].

Negative_regulation (reduce) of lysosomal acid lipase Binding (supplementation) of in plaques associated with atherosclerotic plaque

1) Confidence 0.14 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0.49 Pain Relevance 0

General Comments

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