INT268441

Context Info Confidence 0.07 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.72 Pain Relevance 0

cell differentiation (Gsk3b) carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b) response to stress (Gsk3b) cytoplasm (Gsk3b) cytosol (Gsk3b)

Gsk3b (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 6 5.00 Central nervous system 4 5.00 tolerance 2 5.00 Enkephalin 1 5.00 Inflammatory response 1 5.00 Bile 1 5.00 metalloproteinase 1 5.00 Hippocampus 1 5.00 cva 1 5.00 substance P 1 5.00

Disease Link Frequency Relevance Heat Disease 40 92.40 Alzheimer's Dementia 5 88.68 Injury 3 85.76 Amyloid Plaque 4 57.48 Dementia 1 42.40 Neurodegenerative Disease 1 39.08 Atherosclerosis 17 35.44 Atherosclerotic Plaque 5 18.52 Age-related Macular Degeneration 10 5.00 Ocular Toxicity (including Many Sub-types) 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

is thought to catalyze the formation of NFTs [84,92,93], affecting tau proteins through regulation of glycogen synthase kinase-3 (GSK3) activity [94,95] and activation of cyclin-dependent kinase 5 (CDK5) [96].

Regulation (affecting) of Regulation (regulation) of GSK3

1) Confidence 0.07 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0.72 Pain Relevance 0

General Comments

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