INT268477

Context Info Confidence 0.31 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.63 Pain Relevance 0.25

extracellular region (Igfbp5)

Anatomy Link Frequency eye 1 Igfbp5 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 6 90.40 long-term potentiation 24 5.00 GABAergic 16 5.00 gABA 14 5.00 depression 12 5.00 nMDA receptor 8 5.00 Serotonin 8 5.00 fluoxetine 6 5.00 tetrodotoxin 6 5.00 Glutamate 6 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 6 90.40 Non-genital Cutaneous Warts 6 63.76 Scotoma 2 37.28 Aids-related Complex 30 5.00 Depression 12 5.00 Targeted Disruption 10 5.00 Cancer 2 5.00 Necrosis 2 5.00 Brain Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Increasing the IGF1/IGFBP5 ratio through exogenous IGF1 prevented the effects of MD, suggesting that reduced IGF1 signalling is a necessary step for eliciting the plastic changes evoked by MD.

Positive_regulation (Increasing) of IGFBP5

1) Confidence 0.31 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674480 Disease Relevance 0.32 Pain Relevance 0.13

In support of this idea, Tropea et al. (2006) found that cortical levels of a specific insulin-like growth factor (IGF1)-binding protein, IGFBP5, were upregulated contralateral to the deprived eye, and that deprivation-induced increases in IGFBP5 were critical for the ocular dominance shift.

Positive_regulation (increases) of IGFBP5 in eye

2) Confidence 0.28 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674480 Disease Relevance 0.31 Pain Relevance 0.13

General Comments

This test has worked.