INT268477
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Increasing the IGF1/IGFBP5 ratio through exogenous IGF1 prevented the effects of MD, suggesting that reduced IGF1 signalling is a necessary step for eliciting the plastic changes evoked by MD. | |||||||||||||||
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In support of this idea, Tropea et al. (2006) found that cortical levels of a specific insulin-like growth factor (IGF1)-binding protein, IGFBP5, were upregulated contralateral to the deprived eye, and that deprivation-induced increases in IGFBP5 were critical for the ocular dominance shift. | |||||||||||||||
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General Comments
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