INT268477

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.63
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Igfbp5)
Anatomy Link Frequency
eye 1
Igfbp5 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 6 90.40 High High
long-term potentiation 24 5.00 Very Low Very Low Very Low
GABAergic 16 5.00 Very Low Very Low Very Low
gABA 14 5.00 Very Low Very Low Very Low
depression 12 5.00 Very Low Very Low Very Low
nMDA receptor 8 5.00 Very Low Very Low Very Low
Serotonin 8 5.00 Very Low Very Low Very Low
fluoxetine 6 5.00 Very Low Very Low Very Low
tetrodotoxin 6 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 6 90.40 High High
Non-genital Cutaneous Warts 6 63.76 Quite High
Scotoma 2 37.28 Quite Low
Aids-related Complex 30 5.00 Very Low Very Low Very Low
Depression 12 5.00 Very Low Very Low Very Low
Targeted Disruption 10 5.00 Very Low Very Low Very Low
Cancer 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Brain Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increasing the IGF1/IGFBP5 ratio through exogenous IGF1 prevented the effects of MD, suggesting that reduced IGF1 signalling is a necessary step for eliciting the plastic changes evoked by MD.
Positive_regulation (Increasing) of IGFBP5
1) Confidence 0.31 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674480 Disease Relevance 0.32 Pain Relevance 0.13
In support of this idea, Tropea et al. (2006) found that cortical levels of a specific insulin-like growth factor (IGF1)-binding protein, IGFBP5, were upregulated contralateral to the deprived eye, and that deprivation-induced increases in IGFBP5 were critical for the ocular dominance shift.
Positive_regulation (increases) of IGFBP5 in eye
2) Confidence 0.28 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674480 Disease Relevance 0.31 Pain Relevance 0.13

General Comments

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