INT26849

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Context Info
Confidence 0.61
First Reported 1984
Last Reported 2004
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.29
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Hrh1) plasma membrane (Hrh1) nucleus (Hrh1)
cytoplasm (Hrh1) signal transducer activity (Hrh1)
Anatomy Link Frequency
brain 1
arterioles 1
astrocytes 1
Hrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 8 100.00 Very High Very High Very High
agonist 4 100.00 Very High Very High Very High
tetrodotoxin 7 98.76 Very High Very High Very High
adenocard 1 97.96 Very High Very High Very High
sodium channel 5 95.16 Very High Very High Very High
substance P 1 92.80 High High
Enkephalin 2 88.44 High High
gABA 8 85.24 High High
Potency 3 81.68 Quite High
antinociception 1 79.48 Quite High
Disease Link Frequency Relevance Heat
Vertigo 2 95.56 Very High Very High Very High
Nociception 1 75.00 Quite High
Increased Venous Pressure Under Development 1 68.56 Quite High
Ganglion Cysts 1 52.32 Quite High
Vomiting 1 47.84 Quite Low
Hyperalgesia 1 39.08 Quite Low
INFLAMMATION 1 38.56 Quite Low
Pain 1 27.08 Quite Low
Ocular Toxicity (including Many Sub-types) 3 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, while histamine H1 participates in both phases, 5-hydroxytryptamine(4/3) participates in phase 1 and 5-hydroxytryptamine(1A) in phase 2.
Gene_expression (participates) of histamine H1
1) Confidence 0.61 Published 2001 Journal Neuroscience Section Abstract Doc Link 11182255 Disease Relevance 0.07 Pain Relevance 0.18
H2-receptor but not H1-receptor antagonists, administered by intravenous infusion, produce a dose-dependent constriction of superior mesenteric arterioles of the anaesthetized rat under resting conditions.
Gene_expression (produce) of H1-receptor in arterioles associated with antagonist
2) Confidence 0.17 Published 1989 Journal Farmaco Section Abstract Doc Link 2570587 Disease Relevance 0.07 Pain Relevance 0.20
Unlike histamine H1-receptor blockers, vasodilators such as cinnarizine, ifenprodil and adenosine triphosphate, which are effective in treatment of vertigo, produce an enhancement of responsiveness of neuron activities in the vestibular nuclei, probably as a result of an increase in blood flow in the brain.
Gene_expression (blockers) of H1-receptor in brain associated with adenocard and vertigo
3) Confidence 0.13 Published 1984 Journal Acta Otolaryngol Suppl Section Abstract Doc Link 6399658 Disease Relevance 0.10 Pain Relevance 0.46
Evidence suggesting that the H3 receptor plays a key role in vestibular compensation comes from studies indicating that betahistine, a histamine-like drug that acts as both a partial histamine H1 receptor agonist and an H3 receptor antagonist [14,35], accelerates the process of vestibular compensation [32,36].
Spec (partial) Gene_expression (agonist) of H1 receptor associated with antagonist and agonist
4) Confidence 0.06 Published 2004 Journal BMC Neurosci Section Body Doc Link PMC517932 Disease Relevance 0 Pain Relevance 0.17
Since TTX-resistant current is not present in stellate astrocytes, the presence of rH1 mRNA and protein in these cells suggests, in addition, that post-translational mechanisms participate in the control of sodium channel expression in these cells.
Gene_expression (presence) of rH1 in astrocytes associated with tetrodotoxin and sodium channel
5) Confidence 0.02 Published 1998 Journal Glia Section Abstract Doc Link 9633805 Disease Relevance 0.05 Pain Relevance 0.54

General Comments

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