INT268493

Context Info Confidence 0.01 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.80 Pain Relevance 0.07

pigmentation (Szt2) peroxisome (Szt2) cytoskeleton (Dnm1) GTPase activity (Dnm1) protein complex (Dnm1) cytoplasm (Dnm1)

Dnm1 (Mus musculus) Szt2 (Mus musculus)

Pain Link Frequency Relevance Heat Glutamate receptor 2 83.36 depression 6 55.20 cytokine 1 33.52 Hippocampus 1 29.68 long-term potentiation 12 5.00 GABAergic 8 5.00 gABA 7 5.00 nMDA receptor 4 5.00 Serotonin 4 5.00 fluoxetine 3 5.00

Disease Link Frequency Relevance Heat Aids-related Complex 15 100.00 Non-genital Cutaneous Warts 3 58.00 Depression 6 55.20 Necrosis 1 34.44 Cancer 1 34.08 Targeted Disruption 5 5.00 INFLAMMATION 3 5.00 Scotoma 1 5.00 Brain Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

During periods of increased activity, Arc interacts directly with dynamin to enhance the rate of endocytosis of AMPARs (Chowdhury et al. 2006; Rial Verde et al. 2006), thereby reducing total synaptic strength while leaving relative synaptic weights unchanged.

dynamin Binding (interacts) of increased associated with aids-related complex

1) Confidence 0.01 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674480 Disease Relevance 0.80 Pain Relevance 0.07

General Comments

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