INT26850

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Context Info
Confidence 0.32
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 9.40
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
CD86 1
macrophages 1
blood 1
H2 (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 8 99.48 Very High Very High Very High
Potency 4 98.56 Very High Very High Very High
antagonist 10 95.92 Very High Very High Very High
Inflammatory response 10 89.92 High High
Serotonin 187 89.68 High High
headache 11 86.20 High High
Dopamine 55 84.80 Quite High
anesthesia 15 78.64 Quite High
ischemia 3 78.16 Quite High
imagery 50 77.12 Quite High
Disease Link Frequency Relevance Heat
Adhesions 1 99.54 Very High Very High Very High
Endometriosis (extended) 52 99.22 Very High Very High Very High
Stress 96 98.80 Very High Very High Very High
Infection 103 98.66 Very High Very High Very High
Parkinson's Disease 445 98.56 Very High Very High Very High
Cytomegalovirus Infection 10 98.46 Very High Very High Very High
Systemic Mastocytosis 6 97.94 Very High Very High Very High
Hypotension 6 96.56 Very High Very High Very High
Urological Neuroanatomy 3 95.12 Very High Very High Very High
Disease 197 93.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However the possibility that this effect could be related to a blockade of H2 receptors is unlikely, since their potency on blood flow changes does not parallel known H2-receptor antagonist activity.
Negative_regulation (blockade) of H2 in blood associated with antagonist and potency
1) Confidence 0.32 Published 1989 Journal Farmaco Section Abstract Doc Link 2570587 Disease Relevance 0.08 Pain Relevance 0.23
All kinds of I/R induced an upregulation of the adhesion molecule CD 11b and a downregulation of MHC II.
Negative_regulation (downregulation) of MHC II associated with adhesions
2) Confidence 0.25 Published 2010 Journal APMIS Section Abstract Doc Link 20132173 Disease Relevance 1.17 Pain Relevance 0.31
Consequently, the protective effect of H2 was proved by two different counting methods.
Negative_regulation (effect) of H2
3) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.53 Pain Relevance 0.03
To test whether or not drinking H2/Mg water was effective even after suffering oxidative stress, we compared two different procedures (Figure 3B); one was giving H2/Mg water 7 days prior to the acute MPTP administration (Figure 3B; shown as i) and the other giving H2/Mg water only after MPTP administration (Figure 3B; shown as ii).
Negative_regulation (giving) of H2 associated with parkinson's disease and stress
4) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.85 Pain Relevance 0
We also tested the effect of Mg and other metal elements, Al and Zn which might possibly exist in H2/Mg water, by leaving the H2/Mg water for 24 h (degassed H2/Mg water) so that all the H2 had gone.
Negative_regulation (degassed) of H2
5) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.99 Pain Relevance 0
Although inhalation of H2 may act more rapidly, it is not practical in daily life or suitable for continuous consumption.
Negative_regulation (inhalation) of H2
6) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.70 Pain Relevance 0.20
We also tested the effect of Mg and other metal elements, Al and Zn which might possibly exist in H2/Mg water, by leaving the H2/Mg water for 24 h (degassed H2/Mg water) so that all the H2 had gone.
Negative_regulation (leaving) of H2
7) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747267 Disease Relevance 0.99 Pain Relevance 0
PMA, which is known to cause B cell activation [36], resulted in the upregulation of CD40, CD86, and CD80 and the downregulation of MHC II.
Negative_regulation (downregulation) of MHC II in CD86
8) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871797 Disease Relevance 0.07 Pain Relevance 0.11
Although self-reactive TH1 cells are present, we hypothesize that E2's suppression of MHC II prevents them from becoming activated, and therefore while sufficient E2 is present they fail to attack tissues.
Negative_regulation (suppression) of MHC II
9) Confidence 0.09 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0.32 Pain Relevance 0.15
Murine CMV (MCMV) does not encode an IL-10 homolog, although, parallel to the studies of Flano et al. on dendritic cells infected with MHV68 [36] , in vitro MCMV infection of primary macrophages results in secretion of cellular IL-10 and downregulation of MHC II [58].
Negative_regulation (downregulation) of MHC II in macrophages associated with cytomegalovirus infection and infection
10) Confidence 0.09 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 1.33 Pain Relevance 0
Following menopause, or when E2 levels are unusually low, suppression of MHC II and immune function is lost, allowing self-reactive TH1 cells to become active and pathogenic.
Negative_regulation (suppression) of MHC II associated with endometriosis (extended)
11) Confidence 0.06 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0.46 Pain Relevance 0.23
Cyclooxygenase inhibition, combined with H1 and H2 blockade, is an effective treatment for this condition, but for these patients initiation of aspirin therapy should be carried out with extreme care.
Negative_regulation (blockade) of H2 associated with aspirin
12) Confidence 0.04 Published 1987 Journal Clin Invest Med Section Abstract Doc Link 2880686 Disease Relevance 0.77 Pain Relevance 0.30
Based upon the experience of others with the management of patients with systemic mastocytosis who showed exceptional reaction to cyclooxygenase inhibition, it was decided to treat him with H1 and H2 blockade followed by aspirin, another cyclooxygenase inhibitor.
Negative_regulation (blockade) of H2 associated with aspirin and systemic mastocytosis
13) Confidence 0.04 Published 1987 Journal Clin Invest Med Section Abstract Doc Link 2880686 Disease Relevance 0.83 Pain Relevance 0.25
The expression of MHC-II appears to be higher in cells located further away from the parasite (Figure 7G) suggesting that molecules released by the parasite may downregulate MHC-II.


Spec (may) Negative_regulation (downregulate) of MHC-II
14) Confidence 0.02 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.30 Pain Relevance 0.03

General Comments

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