INT268558

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.70
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CTGF) Golgi apparatus (CTGF) cytosol (CTGF)
extracellular space (CTGF) extracellular region (CTGF) proteinaceous extracellular matrix (CTGF)
Anatomy Link Frequency
connective tissue 3
extracellular matrix 2
CTGF (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 13 100.00 Very High Very High Very High
alcohol 4 81.84 Quite High
anesthesia 12 75.76 Quite High
Inflammation 25 73.04 Quite High
fibrosis 13 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Chronic pancreatitis 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 22 96.56 Very High Very High Very High
Apoptosis 46 93.48 High High
Lymphatic System Cancer 10 92.32 High High
Cancer 273 91.92 High High
Malignant Neoplastic Disease 6 91.36 High High
Liver Cancer 6 90.44 High High
Colon Cancer 10 89.52 High High
Metastasis 10 88.68 High High
Metabolic Disorder 4 84.64 Quite High
Muscle Disease 12 84.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is known that Myc enhances angiogenesis by down regulating antiangiogenic thrombospondin-1 (Tsp1) and related proteins, such as connective tissue growth factor (CTGF).
Regulation (regulating) of CTGF in connective tissue
1) Confidence 0.23 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.91 Pain Relevance 0
It is known that Myc enhances angiogenesis by down regulating antiangiogenic thrombospondin-1 (Tsp1) and related proteins, such as connective tissue growth factor (CTGF).
Regulation (regulating) of tissue growth factor in connective tissue
2) Confidence 0.20 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.91 Pain Relevance 0
The 26 genes that were significantly dysregulated (23 up-regulated and three down-regulated) in the group B samples mainly encoded proteins involved in immune response (interferon pathway, growth factor, growth factor receptor, cytokine: IL8, CXCR4, CCL2, CXCL1, IL6, CCL3, CCL4, LIF) and matrix remodeling (angiogenesis, extracellular matrix, extracellular matrix protease, inhibitors of matrix protease: PAI1, THBS1, PTGS2, HIF1A, MMP9, CTGF, HAS2, PAI2, and MMP2).
Regulation (dysregulated) of CTGF in extracellular matrix associated with cytokine
3) Confidence 0.07 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 1.01 Pain Relevance 0.17
The 26 genes that were significantly dysregulated (23 up-regulated and three down-regulated) in the group B samples mainly encoded proteins involved in immune response (interferon pathway, growth factor, growth factor receptor, cytokine: IL8, CXCR4, CCL2, CXCL1, IL6, CCL3, CCL4, LIF) and matrix remodeling (angiogenesis, extracellular matrix, extracellular matrix protease, inhibitors of matrix protease: PAI1, THBS1, PTGS2, HIF1A, MMP9, CTGF, HAS2, PAI2, and MMP2).
Regulation (dysregulated) of CTGF in extracellular matrix associated with cytokine
4) Confidence 0.03 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 1.01 Pain Relevance 0.17
In our studies of TAO, we have investigated the nature and significance of antibodies targeting other eye muscle and orbital connective tissue (OCT) antigens.
Spec (investigated) Regulation (targeting) of orbital connective tissue in OCT
5) Confidence 0.01 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Abstract Doc Link PMC2874268 Disease Relevance 0.86 Pain Relevance 0.04

General Comments

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