INT268576

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Context Info
Confidence 0.64
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 8
Disease Relevance 2.26
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (THBS1) extracellular region (THBS1) cell adhesion (THBS1)
structural molecule activity (THBS1)
Anatomy Link Frequency
synapses 2
THBS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 6 98.24 Very High Very High Very High
Gabapentin 6 93.52 High High
Inflammation 6 77.12 Quite High
endometriosis 21 75.20 Quite High
ischemia 6 74.48 Quite High
visual analogue scale 1 56.08 Quite High
Pain 2 54.24 Quite High
pain pelvic 15 53.04 Quite High
cytokine 6 52.76 Quite High
Dismenorea 6 51.96 Quite High
Disease Link Frequency Relevance Heat
Wound Healing 12 99.20 Very High Very High Very High
Repression 6 95.68 Very High Very High Very High
Cancer 214 84.76 Quite High
Apoptosis 28 78.72 Quite High
Lymphatic System Cancer 5 77.56 Quite High
INFLAMMATION 6 77.12 Quite High
Malignant Neoplastic Disease 1 76.60 Quite High
Foreign-body Reaction 6 76.12 Quite High
Endometriosis 32 75.20 Quite High
Cv Unclassified Under Development 6 74.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, we verified that the DNA binding domain and DNA binding ability of E2F-1 were required for transactivating TSP1 expression.
Positive_regulation (transactivating) of Gene_expression (expression) of TSP1
1) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
These observations suggested that the DNA binding activity of E2F1 is required for inducing TSP1 expression.
Positive_regulation (inducing) of Gene_expression (expression) of TSP1
2) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
To further verify E2F-1 binding sites in the promoter of TSP1, on the basis of TSP1-promoter (?
Positive_regulation (verify) of Gene_expression (basis) of TSP1
3) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0 Pain Relevance 0
Targeted overexpression of TSP1 in mice suppressed wound healing and tumorigenesis, while lack of functional TSP1 resulted in increased vascularization of selected tissues and significantly decreased the number of excitatory synapses [13], [21], [30].
Positive_regulation (overexpression) of Gene_expression (overexpression) of TSP1 in synapses associated with wound healing
4) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0.90 Pain Relevance 0.24
Then, we did dose response experiments for E2F-1 overexpression on TSP1 promoter activity.
Positive_regulation (overexpression) of Gene_expression (overexpression) of TSP1
5) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0.10 Pain Relevance 0
Flag empty vector or different dose of Flag-tagged E2F-1 expression vector, TSP1(?
Positive_regulation (tagged) of Gene_expression (expression) of TSP1
6) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955548 Disease Relevance 0.09 Pain Relevance 0
All results of thrombospondin-1 expression were analysed by the Student's t-test.
Positive_regulation (results) of Gene_expression (expression) of thrombospondin-1
7) Confidence 0.37 Published 2009 Journal J Ovarian Res Section Body Doc Link PMC2785805 Disease Relevance 0.44 Pain Relevance 0.22
Anti-sense 2’-O-methyl oligoribonucleotides targeting the miRNAs from this cluster caused partial restoration of Tsp1 and CTGF expression.
Spec (partial) Positive_regulation (caused) of Gene_expression (expression) of Tsp1
8) Confidence 0.14 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.73 Pain Relevance 0

General Comments

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