INT26858

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Context Info
Confidence 0.32
First Reported 1989
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.63
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ADRA2C) small molecule metabolic process (ADRA2C) plasma membrane (ADRA2C)
cell-cell signaling (ADRA2C) cytoplasm (ADRA2C) signal transducer activity (ADRA2C)
Anatomy Link Frequency
HT-29 4
bowel 2
ADRA2C (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 7 96.56 Very High Very High Very High
spastic colon 1 92.40 High High
Inflammation 5 75.00 Quite High
Clonidine 4 43.68 Quite Low
sodium channel 2 25.00 Low Low
antagonist 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 2 96.24 Very High Very High Very High
Functional Bowel Disorder 1 92.40 High High
INFLAMMATION 5 75.00 Quite High
Enteropathy 1 75.00 Quite High
Constipation 1 72.72 Quite High
Ileus 2 64.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether the various receptor-effector coupling mechanisms operate in a tissue-specific manner, we studied the effect of alpha 2-AR activation on basal and stimulated Na+/H+ exchange in epithelial cells isolated from human colon (HT-29 adenocarcinoma cells).
Regulation (effect) of Positive_regulation (activation) of alpha 2-AR in HT-29 associated with adenocarcinoma
1) Confidence 0.32 Published 1989 Journal J. Biol. Chem. Section Abstract Doc Link 2570777 Disease Relevance 0.10 Pain Relevance 0.04
To determine whether the various receptor-effector coupling mechanisms operate in a tissue-specific manner, we studied the effect of alpha 2-AR activation on basal and stimulated Na+/H+ exchange in epithelial cells isolated from human colon (HT-29 adenocarcinoma cells).
Regulation (effect) of Positive_regulation (activation) of alpha 2-AR in HT-29 associated with adenocarcinoma
2) Confidence 0.32 Published 1989 Journal J. Biol. Chem. Section Abstract Doc Link 2570777 Disease Relevance 0.10 Pain Relevance 0.04
Studies in humans have shown a favourable influence of alpha2-adrenoceptor activation on colonic tone and sensation, and there is clinical evidence indicating that alpha2-agonists can improve intestinal functions and induce a satisfactory relief of symptoms in patients with irritable bowel syndrome.
Regulation (influence) of Positive_regulation (activation) of alpha2-adrenoceptor in bowel associated with spastic colon and agonist
3) Confidence 0.19 Published 2007 Journal Neurochem. Int. Section Abstract Doc Link 17618014 Disease Relevance 0.43 Pain Relevance 0.21

General Comments

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