INT268582

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 15
Disease Relevance 9.99
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lymphocytes 3
blood 1
MIR17 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 1266 99.84 Very High Very High Very High
Inflammation 228 87.52 High High
Bile 2 82.72 Quite High
cytokine 216 75.80 Quite High
tolerance 40 73.28 Quite High
Central nervous system 222 27.92 Quite Low
Chronic pancreatitis 7 14.40 Low Low
Demyelination 34 5.00 Very Low Very Low Very Low
Inflammatory response 32 5.00 Very Low Very Low Very Low
chemokine 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 1522 99.84 Very High Very High Very High
Autoimmune Disease 378 99.54 Very High Very High Very High
Lymphoproliferative Disease 32 99.20 Very High Very High Very High
Disease 601 98.80 Very High Very High Very High
Adenocarcinoma 21 98.44 Very High Very High Very High
Carcinoma 22 98.40 Very High Very High Very High
Lymphatic System Cancer 19 97.72 Very High Very High Very High
Cancer 776 97.68 Very High Very High Very High
Apoptosis 134 93.20 High High
Sarcoma 14 91.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This in combination with our study design that included the three major subgroups of MS whereas the patients participating in the Lindberg report were diagnosed with relapsing remitting disease only could potentially explain the differences observed in miR-17 expression.
Gene_expression (expression) of miR-17 associated with disease and demyelinating disease
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920328 Disease Relevance 0.46 Pain Relevance 0
Elevated expression of miR-17 and related miRNAs has been found to be associated with lymphoma and other cancers, and is probably important in maintaining an undifferentiated phenotype and resisting apoptosis [21], [22].
Gene_expression (expression) of miR-17 associated with lymphatic system cancer, cancer and apoptosis
2) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920328 Disease Relevance 0.74 Pain Relevance 0
As that of miR-21, miR-17-5p is overexpressed (shown with solid lines in Figure 1) in their associated tumor types, showing strong oncogenic characteristics.
Gene_expression (overexpressed) of miR-17-5p associated with cancer
3) Confidence 0.10 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.11 Pain Relevance 0.04
Treatment of Panc-1 with G2535 elicited decreased expression of the oncogenic miRNAs miR-17, miR-20a, miR-106a, miR-222 and increased expression of the tumor suppressor miRNAs let-7a, let-7d, let-7e and let-7f.
Gene_expression (expression) of oncogenic miRNAs miR-17 associated with cancer
4) Confidence 0.09 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.57 Pain Relevance 0
In regards to Colo-357, treatment with B-DIM showed decreased expression of the oncogenic miRNAs miR-17, miR-19b-1, miR-20a and miR-106a.
Gene_expression (expression) of oncogenic miRNAs miR-17
5) Confidence 0.09 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.48 Pain Relevance 0
However, in a larger and more recent study, Cox et al. showed that miR-17 is underexpressed in MS whole blood [260].
Gene_expression (underexpressed) of miR-17 in blood associated with multiple sclerosis
6) Confidence 0.07 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.58 Pain Relevance 0.16
While these miRNAs target AML1, this transcription factor binds and transcriptionally inhibits expression of miR-17-5p, miR-20a, and miR-106a in a mutual negative feedback loop [128].
Gene_expression (expression) of miR-17
7) Confidence 0.07 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.22 Pain Relevance 0
Falling into this category is the group of six miRNAs termed the miR-17-92 cluster which is made up of miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1, and miR-92-1 [49].
Gene_expression (made) of miR-17
8) Confidence 0.07 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674802 Disease Relevance 0.86 Pain Relevance 0
Further support for a causal relationship between specific miRNAs and the onset of autoimmunity has come from studies involving miR-17–92 overexpression in mice [102].
Gene_expression (overexpression) of miR-17 associated with autoimmune disease
9) Confidence 0.06 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.88 Pain Relevance 0.17
Mice with higher expression of miR-17–92 in lymphocytes developed lymphoproliferative disease and autoimmunity and died prematurely. miR-17–92 overexpression promoted marked lymphoproliferation, the presence of serum autoantibodies, and tissue changes such as lymphoid infiltrates and antibody deposition.
Gene_expression (expression) of miR-17 in lymphocytes associated with autoimmune disease and lymphoproliferative disease
10) Confidence 0.06 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.92 Pain Relevance 0.16
This was correlated with alterations in the expression of potential target genes of miR-17-5p, that is, phosphatase and tensin homology and phosphatidyl-inositol-3-kinase regulatory subunit 1, which were downregulated upon stimulation of CD4+ cells in vitro.
Gene_expression (expression) of miR-17
11) Confidence 0.06 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.48 Pain Relevance 0.16
Lipopolysaccharide (LPS) stimulation decreased expression of miRNAs, miR-17-5, miR-20a, and miR-93, which target MICA, implicating a novel role for miRNAs in NKG2D ligand expression.
Gene_expression (expression) of miR-17
12) Confidence 0.06 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.52 Pain Relevance 0
Mice with higher expression of miR-17–92 in lymphocytes developed lymphoproliferative disease and autoimmunity and died prematurely. miR-17–92 overexpression promoted marked lymphoproliferation, the presence of serum autoantibodies, and tissue changes such as lymphoid infiltrates and antibody deposition.
Gene_expression (overexpression) of miR-17 in lymphocytes associated with autoimmune disease and lymphoproliferative disease
13) Confidence 0.06 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.81 Pain Relevance 0.11
Mice with higher expression of miR-17–92 in lymphocytes developed lymphoproliferative disease and autoimmunity and died prematurely.
Gene_expression (expression) of miR-17 in lymphocytes associated with autoimmune disease and lymphoproliferative disease
14) Confidence 0.05 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 0.45 Pain Relevance 0.10
Patients with high expression of either miR-155, miR-17-3p, miR-106a, miR-93 or miR-21 and low expression of either let-7a-2, let-7b or miR-145 were found to have a significantly worse prognosis.
Gene_expression (expression) of miR-17-3p
15) Confidence 0.04 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 0.91 Pain Relevance 0

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