INT268620

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Context Info
Confidence 0.35
First Reported 2009
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.12
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gsk3b) carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b)
response to stress (Gsk3b) cytoplasm (Gsk3b) cytosol (Gsk3b)
Anatomy Link Frequency
neurons 2
Gsk3b (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 38 93.56 High High
ischemia 4 93.36 High High
Dopamine 7 83.04 Quite High
Eae 3 21.00 Low Low
depression 2 12.80 Low Low
Substantia nigra 8 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Neuritis 2 5.00 Very Low Very Low Very Low
dopaminergic neurodegeneration 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 81 99.28 Very High Very High Very High
Impaired Glucose Tolerance 28 93.56 High High
Cv Unclassified Under Development 4 93.36 High High
Shock 8 92.16 High High
Diabetes Mellitus 28 88.96 High High
Death 74 73.60 Quite High
Parkinson's Disease 80 62.16 Quite High
Sprains And Strains 67 59.44 Quite High
Obesity 12 57.08 Quite High
Disease 47 55.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, based on these findings and considering the lack of effect of hepatic deletion of GSK-3?
Regulation (effect) of Localization (deletion) of GSK-3
1) Confidence 0.35 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.20 Pain Relevance 0.03
These observations led us to investigate which tissues are responsible for the phenotype observed in the GSK-3?
Regulation (responsible) of Localization (observed) of GSK-3
2) Confidence 0.35 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 1.11 Pain Relevance 0.12
Further illustrating the importance of GSK3?
Regulation (illustrating) of Localization (importance) of GSK3
3) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797305 Disease Relevance 0.16 Pain Relevance 0.04
Indeed, in MPP+-treated neurons, the active form of GSK-3?
Regulation (neurons) of Localization (form) of GSK-3 in neurons
4) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.41 Pain Relevance 0.04
amount and its distribution do not appear to be affected by MPP+ treatment, we cannot rule out the possibility of a translocation of the active form of GSK-3?
Spec (possibility) Regulation (possibility) of Localization (translocation) of GSK-3
5) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.23 Pain Relevance 0.05

General Comments

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