INT268629

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Context Info
Confidence 0.26
First Reported 2009
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.05
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gsk3b) carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b)
response to stress (Gsk3b) cytoplasm (Gsk3b) cytosol (Gsk3b)
Anatomy Link Frequency
neuron 2
Mpz (Mus musculus)
Gsk3b (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 4 51.44 Quite High
Substantia nigra 8 18.92 Low Low
dopaminergic neurodegeneration 2 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Neuritis 2 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 14 90.72 High High
Death 74 86.32 High High
Disease 46 83.64 Quite High
Parkinson's Disease 80 80.20 Quite High
Shock 8 70.00 Quite High
Stress 10 56.40 Quite High
Cv Unclassified Under Development 4 51.44 Quite High
Apoptosis 12 48.60 Quite Low
Alzheimer's Dementia 2 12.36 Low Low
Neurodegenerative Disease 10 8.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, MPP+ does not appear to regulate the Akt-mediated phosphorylation of GSK-3?
MPP Spec (appear) Regulation (regulate) of Phosphorylation (phosphorylation) of GSK-3
1) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.53 Pain Relevance 0.03
Immortalized murine cortical neurons (TSM1) or primary cultures of neuronal cells were incubated in the presence of MPP+ iodide then Western blot analyses were performed on neuron homogenates in order to examine the effect of MPP+ on the phosphorylation of GSK-3?
MPP Spec (examine) Regulation (effect) of Phosphorylation (phosphorylation) of GSK-3 in neuron
2) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.52 Pain Relevance 0

General Comments

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