INT268677

Context Info Confidence 0.05 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.75 Pain Relevance 0.05

nucleoplasm (XRCC1) extracellular space (IFNA2) extracellular region (IFNA2) nucleus (XRCC1) intracellular (XRCC1) cell-cell signaling (IFNA2)

IFNA2 (Homo sapiens) XRCC1 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 1 99.80 addiction 4 5.00 Pain 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Renal Cancer 55 100.00 Cancer 101 80.40 Metastasis 7 75.56 Adhesions 6 71.60 Disease 6 41.84 Apoptosis 8 7.84 Hypoxia 7 5.00 Breast Cancer 6 5.00 Colon Cancer 3 5.00 Wiskott-aldrich Syndrome 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Considering that RCC is resistant to chemo, radio and hormonal therapy while immunotherapy (cytokines IL-2 and interferon-alpha) appears to be effective for RCC treatment, these immune response related biomarkers could be potentially important for therapeutics.

interferon-alpha Positive_regulation (effective) of RCC associated with renal cancer and cytokine

1) Confidence 0.05 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 0.75 Pain Relevance 0.05

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