INT268679

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Context Info
Confidence 0.17
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.80
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (HDAC1, NCOR2) nucleolus (HDAC1, NCOR2) nucleus (HDAC1, NCOR2)
small molecule metabolic process (NCOR2) DNA binding (NCOR2) enzyme binding (HDAC1)
HDAC1 (Homo sapiens)
NCOR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 8 75.12 Quite High
Bioavailability 6 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
anticonvulsant 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 249 98.92 Very High Very High Very High
Disease 23 98.20 Very High Very High Very High
Renal Cancer 110 96.72 Very High Very High Very High
Lung Cancer 5 83.04 Quite High
Hypoxia 14 78.72 Quite High
Reprotox - General 1 4 76.08 Quite High
Repression 1 72.44 Quite High
Hematologic Neoplasms 8 62.96 Quite High
Adenocarcinoma 2 58.40 Quite High
Adhesions 12 52.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(II) These genes include NCOR2 (SMRT, up), which forms a large co-repressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2.
HDAC1 Binding (complex) of SMRT
1) Confidence 0.17 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.33 Pain Relevance 0.04
(II) These genes include NCOR2 (SMRT, up), which forms a large co-repressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2.
HDAC1 Binding (complex) of NCOR2
2) Confidence 0.17 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.33 Pain Relevance 0.04
HDAC class I and II interact with adaptor protein like mSin3A and transcriptional co-repressors N-CoR and SMRT to repress gene transcription [31].
HDAC class I Binding (interact) of SMRT
3) Confidence 0.04 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.13 Pain Relevance 0

General Comments

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