INT268685

Context Info Confidence 0.31 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.28 Pain Relevance 0.05

transport (SLC25A5) mitochondrion (SLC25A5) small molecule metabolic process (SLC25A5) chromosome segregation (SLC25A5) transmembrane transport (SLC25A5)

SLC25A5 (Homo sapiens)

Pain Link Frequency Relevance Heat addiction 4 97.00 cytokine 1 5.00 Pain 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Renal Cancer 55 99.60 Cancer 101 93.80 Hypoxia 7 93.28 Lung Cancer 2 78.24 Disease 6 59.52 Metastasis 7 28.68 Apoptosis 8 22.56 Reprotox - General 1 2 10.64 Breast Cancer 6 5.00 Adhesions 6 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Renal carcinomas were found to have reduced levels of ANT2 and other oxidative phosphorylation genes (Heddi et al. 1996) in line with the argument that the loss of cell dependence on oxidative metabolism is an important factor in the development of tumors under hypoxic conditions (Chevrollier et al. 2005).

Negative_regulation (reduced) of Phosphorylation (phosphorylation) of ANT2 associated with addiction, hypoxia, cancer and renal cancer

1) Confidence 0.31 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.28 Pain Relevance 0.05

General Comments

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