INT268701

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Context Info
Confidence 0.31
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.61
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SLC25A5) mitochondrion (SLC25A5) small molecule metabolic process (SLC25A5)
chromosome segregation (SLC25A5) transmembrane transport (SLC25A5)
Anatomy Link Frequency
thyroid 1
SLC25A5 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 4 95.56 Very High Very High Very High
Somatostatin 10 60.08 Quite High
Neurotransmitter 4 28.04 Quite Low
depression 2 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Electroencephalography 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Cancer 55 99.60 Very High Very High Very High
Cancer 119 95.24 Very High Very High Very High
Hypoxia 7 91.84 High High
Parathyroid Cancer 2 90.88 High High
Carcinoid 2 83.64 Quite High
Thyroid Disease 26 83.04 Quite High
Pituitary Cancer 22 82.84 Quite High
Thyroid Hormone Resistance Syndrome 6 81.52 Quite High
Syndrome 4 78.88 Quite High
Lung Cancer 2 75.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Renal carcinomas were found to have reduced levels of ANT2 and other oxidative phosphorylation genes (Heddi et al. 1996) in line with the argument that the loss of cell dependence on oxidative metabolism is an important factor in the development of tumors under hypoxic conditions (Chevrollier et al. 2005).
Negative_regulation (reduced) of ANT2 associated with addiction, hypoxia, cancer and renal cancer
1) Confidence 0.31 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.16 Pain Relevance 0.05
2 mRNA encoding a thyroid hormone receptor variant lacking T3 binding activity might in principle also contribute to irregular secretion [26, 27].
Negative_regulation (lacking) of T3 in thyroid
2) Confidence 0.09 Published 2008 Journal Pituitary Section Body Doc Link PMC2712623 Disease Relevance 0.77 Pain Relevance 0
Indeed, in our case series only two patients had an increased mean TSH concentration (Fig. 2), although the other patients should have had suppressed TSH levels due to elevated T4 (T3) concentrations.
Negative_regulation (suppressed) of T3
3) Confidence 0.08 Published 2008 Journal Pituitary Section Body Doc Link PMC2712623 Disease Relevance 0.68 Pain Relevance 0.03

General Comments

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