INT268701

Context Info Confidence 0.31 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 2.61 Pain Relevance 0.08

transport (SLC25A5) mitochondrion (SLC25A5) small molecule metabolic process (SLC25A5) chromosome segregation (SLC25A5) transmembrane transport (SLC25A5)

Anatomy Link Frequency thyroid 1 SLC25A5 (Homo sapiens)

Pain Link Frequency Relevance Heat addiction 4 95.56 Somatostatin 10 60.08 Neurotransmitter 4 28.04 depression 2 5.00 Dopamine 2 5.00 headache 2 5.00 Electroencephalography 2 5.00 cytokine 1 5.00 Pain 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Renal Cancer 55 99.60 Cancer 119 95.24 Hypoxia 7 91.84 Parathyroid Cancer 2 90.88 Carcinoid 2 83.64 Thyroid Disease 26 83.04 Pituitary Cancer 22 82.84 Thyroid Hormone Resistance Syndrome 6 81.52 Syndrome 4 78.88 Lung Cancer 2 75.36

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Renal carcinomas were found to have reduced levels of ANT2 and other oxidative phosphorylation genes (Heddi et al. 1996) in line with the argument that the loss of cell dependence on oxidative metabolism is an important factor in the development of tumors under hypoxic conditions (Chevrollier et al. 2005).

Negative_regulation (reduced) of ANT2 associated with addiction, hypoxia, cancer and renal cancer

1) Confidence 0.31 Published 2007 Journal Cancer Informatics Section Body Doc Link PMC2675843 Disease Relevance 1.16 Pain Relevance 0.05

2 mRNA encoding a thyroid hormone receptor variant lacking T3 binding activity might in principle also contribute to irregular secretion [26, 27].

Negative_regulation (lacking) of T3 in thyroid

2) Confidence 0.09 Published 2008 Journal Pituitary Section Body Doc Link PMC2712623 Disease Relevance 0.77 Pain Relevance 0

Indeed, in our case series only two patients had an increased mean TSH concentration (Fig. 2), although the other patients should have had suppressed TSH levels due to elevated T4 (T3) concentrations.

Negative_regulation (suppressed) of T3

3) Confidence 0.08 Published 2008 Journal Pituitary Section Body Doc Link PMC2712623 Disease Relevance 0.68 Pain Relevance 0.03

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