INT268725

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Context Info
Confidence 0.35
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.41
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SOD1) peroxisome (SOD1) protein complex (SOD1)
cytoplasm (SOD1) cytosol (SOD1) extracellular space (SOD1)
Anatomy Link Frequency
brain 2
urine 2
SOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Substantia nigra 4 73.12 Quite High
Dopamine 3 69.48 Quite High
Hippocampus 1 58.96 Quite High
Inflammation 11 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 32 98.88 Very High Very High Very High
Targeted Disruption 11 98.12 Very High Very High Very High
Frailty 5 93.76 High High
Alzheimer's Dementia 18 90.68 High High
Metabolic Syndrome 17 89.36 High High
Disorder Of Lipid Metabolism 38 88.32 High High
Parkinson's Disease 13 86.32 High High
Dyslipidemia /

Combined Dyslipidemia

1 78.60 Quite High
Disease 58 77.92 Quite High
Hypertension 8 77.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The consumption of hydrogen rich water for 8 weeks resulted in a 39% increase (p<0.05) in antioxidant enzyme superoxide dismutase (SOD) and a 43% decrease (p<0.05) in thiobarbituric acid reactive substances (TBARS) in urine.
Positive_regulation (increase) of Negative_regulation (decrease) of SOD in urine
1) Confidence 0.35 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Abstract Doc Link PMC2831093 Disease Relevance 0.95 Pain Relevance 0
The depletion in SOD activity was restored by resveratrol treatment (vide infra).
Positive_regulation (restored) of Negative_regulation (depletion) of SOD
2) Confidence 0.19 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2676242 Disease Relevance 0.12 Pain Relevance 0
In addition, increased levels of malondialdehyde and downregulation of SOD, both markers of oxidative stress seen in the transgenic mice, were ameliorated by CoQ10 treatment.73 Supplemental CoQ10 was also found to attenuate brain atrophy at 60 days, as assessed by MRI in vivo, in aged transgenic mice with amyloid precursor protein (APP) mutations.
Positive_regulation (increased) of Negative_regulation (downregulation) of SOD in brain associated with targeted disruption, stress, alzheimer's dementia and frailty
3) Confidence 0.03 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785862 Disease Relevance 1.25 Pain Relevance 0.10

General Comments

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