INT268729

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.89
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc1a2)
Anatomy Link Frequency
astrocytes 2
Slc1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 41 97.96 Very High Very High Very High
Spinal cord 4 92.80 High High
Hippocampus 43 91.36 High High
nMDA receptor 6 76.56 Quite High
amygdala 36 75.80 Quite High
spinal dorsal horn 12 67.76 Quite High
antidepressant 21 50.00 Quite Low
Sciatic nerve 9 50.00 Quite Low
sSRI 14 38.48 Quite Low
Dorsal horn 2 32.36 Quite Low
Disease Link Frequency Relevance Heat
Stress 104 100.00 Very High Very High Very High
Nervous System Injury 13 85.20 High High
Injury 3 77.84 Quite High
Anxiety Disorder 19 62.48 Quite High
Hypersensitivity 4 16.80 Low Low
Depression 33 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 8 5.00 Very Low Very Low Very Low
Cognitive Disorder 5 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low
Mental Disorders 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results from the above suggest that the decrease in GLT-1 and GLAST, which was induced by PNSL, mainly occurred in astrocytes on the injured side.


Negative_regulation (decrease) of Positive_regulation (induced) of GLT-1 in astrocytes
1) Confidence 0.40 Published 2009 Journal Mol Pain Section Body Doc Link PMC2676254 Disease Relevance 0.23 Pain Relevance 0.08
Importantly, tianeptine has been shown to block the stress-induced increase in hippocampal GLT-1 levels.
Negative_regulation (block) of Positive_regulation (increase) of GLT-1 associated with stress
2) Confidence 0.08 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701287 Disease Relevance 0.65 Pain Relevance 0.54

General Comments

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