INT268754

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.76
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ccr1) plasma membrane (Ccr1) cell-cell signaling (Ccr1)
signal transducer activity (Ccr1)
Anatomy Link Frequency
myotube 4
macrophages 2
Ccr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 64 96.24 Very High Very High Very High
chemokine 152 95.08 Very High Very High Very High
cytokine 55 94.48 High High
Inflammatory response 8 88.80 High High
Inflammatory stimuli 8 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 104 98.20 Very High Very High Very High
Muscular Dystrophy 4 98.20 Very High Very High Very High
INFLAMMATION 76 96.24 Very High Very High Very High
Disease 5 91.88 High High
Infection 60 86.40 High High
Adhesions 9 84.32 Quite High
Thrombosis 7 82.80 Quite High
Respiratory Failure 8 80.88 Quite High
Targeted Disruption 4 80.20 Quite High
Endotoxemia 36 78.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
construct prior to LPS stimulation at the myotube stage, there was a significant inhibition of subsequent LPS-induced RANTES expression, whereas IKK?
Negative_regulation (inhibition) of Gene_expression (expression) of RANTES in myotube
1) Confidence 0.43 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.40 Pain Relevance 0.20
For example, in the mdx mouse, a murine model of Duchenne muscular dystrophy, the diaphragm exhibits a pronounced infiltration by macrophages and lymphocyctes, which parallels a marked overexpression of RANTES and MIP-1?
Negative_regulation (parallels) of Gene_expression (overexpression) of RANTES in macrophages associated with muscular dystrophy
2) Confidence 0.42 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.91 Pain Relevance 0.29
In the absence of LPS stimulation, RANTES expression by diaphragmatic myotubes was observed, but only at a very low level, whereas MIP-1?
Negative_regulation (observed) of Gene_expression (expression) of RANTES in myotubes
3) Confidence 0.42 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2676322 Disease Relevance 0.16 Pain Relevance 0.15
Constitutive
                             expression levels of RANTES and MIP-1?
Negative_regulation (levels) of Gene_expression (expression) of RANTES
4) Confidence 0.42 Published 2009 Journal Mediators of Inflammation Section Abstract Doc Link PMC2676322 Disease Relevance 0.81 Pain Relevance 0.21
Specifically, fucoidan treatment reduced the amounts of GM-CSF, IL-6, MCP-1, and RANTES (Fig. 6).
Negative_regulation (reduced) of Gene_expression (amounts) of RANTES
5) Confidence 0.03 Published 2010 Journal The Korean Journal of Hematology Section Body Doc Link PMC2983006 Disease Relevance 0.48 Pain Relevance 0.28

General Comments

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