INT268793

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.54
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ghr) extracellular space (Ghr) extracellular region (Ghr)
plasma membrane (Ghr) nucleus (Ghr) cytoplasm (Ghr)
Ghr (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 20 96.96 Very High Very High Very High
Glutamate 4 73.84 Quite High
Somatostatin 44 5.00 Very Low Very Low Very Low
Dopamine 18 5.00 Very Low Very Low Very Low
agonist 16 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Intracerebroventricular 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Starvation 2 98.26 Very High Very High Very High
Syndrome 8 85.00 Quite High
Laron Syndrome 2 77.92 Quite High
Targeted Disruption 4 60.64 Quite High
Acromegaly 54 50.00 Quite Low
Cancer 24 5.00 Very Low Very Low Very Low
Adenoma 20 5.00 Very Low Very Low Very Low
Disease 14 5.00 Very Low Very Low Very Low
Pituitary Cancer 8 5.00 Very Low Very Low Very Low
Body Weight 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The GH receptor is synthesized and degraded continuously with a half-life of less than 60 minutes.
Protein_catabolism (degraded) of GH receptor
1) Confidence 0.69 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.24 Pain Relevance 0.03
An example of receptor down-regulation is starvation, which leads to high GH and low IGF-I serum concentrations and is caused by increased GH receptor degradation (Strous et al 2004).


Protein_catabolism (degradation) of GH receptor associated with starvation
2) Confidence 0.69 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.29 Pain Relevance 0.09

General Comments

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