INT268840

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Context Info
Confidence 0.10
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.05
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Pitpnc1) signal transduction (Pitpnc1) transport (Pitpnc1)
nucleus (Pitpnc1) intracellular (Pitpnc1) cytoplasm (Pitpnc1)
Anatomy Link Frequency
Gill 2
Pitpnc1 (Mus musculus)
Pain Link Frequency Relevance Heat
vincristine 24 5.00 Very Low Very Low Very Low
iatrogenic 20 5.00 Very Low Very Low Very Low
cryotherapy 4 5.00 Very Low Very Low Very Low
Taxol 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
backache 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sarcoma 332 98.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 136 92.44 High High
Cardiovascular Disorder Under Development 24 83.84 Quite High
Toxicity 24 82.76 Quite High
Cancer 104 53.64 Quite High
Disease 32 31.20 Quite Low
Adenocarcinoma 4 5.24 Low Low
Vomiting 16 5.00 Very Low Very Low Very Low
Alopecia 12 5.00 Very Low Very Low Very Low
Leukopenia 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The liposomal formulation stabilizes DNR, preventing rapid clearance and allowing more time for the drug to accumulate in KS lesions (Forssen et al 1992; Gill et al 1995).
Positive_regulation (stabilizes) of DNR in Gill associated with sarcoma
1) Confidence 0.10 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676651 Disease Relevance 0.61 Pain Relevance 0
These results suggest that the increased stability of liposomal DNR may provide a mechanism by which high cumulative doses may be administered to patients without serious side-effects.
Positive_regulation (increased) of DNR
2) Confidence 0.07 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676651 Disease Relevance 0.32 Pain Relevance 0
These data represent an 11- to 12-fold increase over conventional DNR and reflect the stability of the liposomal carrier as previously described in murine model systems (Forssen et al 1992; Gill et al 1995).
Positive_regulation (increase) of DNR in Gill
3) Confidence 0.07 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676651 Disease Relevance 0.59 Pain Relevance 0
Whether similar formulations of DNR would prove more efficacious in the treatment of KS is unclear since anthracyclines display virtually identical mechanistic properties.
Spec (Whether) Positive_regulation (formulations) of DNR associated with sarcoma
4) Confidence 0.07 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676651 Disease Relevance 0.53 Pain Relevance 0

General Comments

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