INT268846

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.06
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Top2a) nucleoplasm (Top2a) chromosome segregation (Top2a)
enzyme binding (Top2a) DNA binding (Top2a) protein complex (Top2a)
Top2a (Mus musculus)
Pain Link Frequency Relevance Heat
palliative 1 74.64 Quite High
vincristine 6 26.16 Quite Low
Pain 12 26.04 Quite Low
antagonist 1 11.76 Low Low
withdrawal 5 5.84 Low Low
cva 17 5.00 Very Low Very Low Very Low
Inflammation 14 5.00 Very Low Very Low Very Low
cINOD 6 5.00 Very Low Very Low Very Low
iatrogenic 5 5.00 Very Low Very Low Very Low
ischemia 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 14 100.00 Very High Very High Very High
Disease 50 99.72 Very High Very High Very High
Cardiovascular Disorder Under Development 82 98.08 Very High Very High Very High
Injury 38 97.76 Very High Very High Very High
Cancer 119 94.28 High High
Recurrence 4 88.52 High High
Advanced Or Metastatic Breast Cancer 1 84.80 Quite High
Immunotherapy Of Cancer 6 75.96 Quite High
Myocardial Infarction 17 74.96 Quite High
Ovarian Cancer 7 71.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is also underlined by the fact that two other non-chelating catalytic agents, merbarone and aclarubicin, also inhibitors of topoisomerase II, failed to prevent anthracycline-induced extravasation injuries in animals.27,33

Pharmacokinetics/pharmacodynamics

Negative_regulation (inhibitors) of topoisomerase II associated with injury
1) Confidence 0.29 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697522 Disease Relevance 0.31 Pain Relevance 0
Reduction of oxidative stress due to complexes of metal ions and anthracyclines by chelating metal ionsBlockade of topoisomerase II poisons by catalytic inhibition of topoisomerase II
Negative_regulation (inhibition) of topoisomerase II associated with stress
2) Confidence 0.29 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697522 Disease Relevance 0.17 Pain Relevance 0
It has been shown that dexrazoxane reversibly inhibits topoisomerase II.34 However, it is difficult to identify a mechanism by which this could occur, as these tissues are not rapidly proliferating and contain only low levels of topoisomerase II.
Negative_regulation (inhibits) of topoisomerase II
3) Confidence 0.22 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697522 Disease Relevance 0.28 Pain Relevance 0
Several nonplatinum agents have demonstrated activity in recurrent disease, such as the topoisomerase II inhibitor liposomal doxorubicin, the topoisomerase I inhibitor topotecan, the antimetabolite gemcitabine and trabectedin, a drug isolated from the marine organism Ecteinascidia turbinata.
Negative_regulation (inhibitor) of topoisomerase II associated with disease
4) Confidence 0.07 Published 2010 Journal Annals of Oncology Section Body Doc Link PMC2844948 Disease Relevance 0.93 Pain Relevance 0.07
At high concentrations, dexrazoxane also inhibits topoisomerase II, which may also be involved in its cardioprotective activities (89).
Negative_regulation (inhibits) of topoisomerase II
5) Confidence 0.07 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2802286 Disease Relevance 1.09 Pain Relevance 0
Alternatively, the activity of topoisomerase II, an enzyme that relieves torsional stress during DNA synthesis, is also significantly inhibited by DNR (Tewey et al 1984; Froelich-Ammon and Osheroff 1995).
Negative_regulation (inhibited) of topoisomerase II associated with stress
6) Confidence 0.04 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676651 Disease Relevance 0.28 Pain Relevance 0

General Comments

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