INT268847

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Context Info
Confidence 0.24
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.60
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Top2a) nucleoplasm (Top2a) chromosome segregation (Top2a)
enzyme binding (Top2a) DNA binding (Top2a) protein complex (Top2a)
Top2a (Mus musculus)
Pain Link Frequency Relevance Heat
vincristine 6 18.20 Low Low
iatrogenic 5 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
cryotherapy 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Taxol 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cardiovascular Disorder Under Development 7 98.28 Very High Very High Very High
Stress 3 94.36 High High
Injury 12 87.68 High High
Cancer 31 82.76 Quite High
Chromosomal Instability 1 61.76 Quite High
Death 1 58.56 Quite High
Sarcoma 83 51.24 Quite High
Alopecia 3 48.96 Quite Low
Vomiting 6 48.16 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 34 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this paper, the authors discussed the topoisomerase II interaction as the inhibitory mechanism for its efficacy.
topoisomerase II Binding (interaction) of
1) Confidence 0.24 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697522 Disease Relevance 0.27 Pain Relevance 0
Anthracyclines stabilize interaction between topoisomerase II and cleaved DNA, preventing the enzyme from fully resolving DNA breaks (Tewey et al 1984).
topoisomerase II Binding (interaction) of
2) Confidence 0.04 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676651 Disease Relevance 0.33 Pain Relevance 0

General Comments

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