INT268877

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Context Info
Confidence 0.58
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 8
Disease Relevance 4.73
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Vegfa) cell proliferation (Vegfa) extracellular space (Vegfa)
growth (Vegfa) extracellular region (Vegfa) plasma membrane (Vegfa)
Anatomy Link Frequency
vessels 4
granulation 4
Vegfa (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 38 97.92 Very High Very High Very High
Pain 7 86.04 High High
Angina 4 50.44 Quite High
Neuropeptide 7 30.12 Quite Low
chemokine 7 28.56 Quite Low
Thoracotomy 2 7.28 Low Low
ischemia 9 5.00 Very Low Very Low Very Low
Lasting pain 7 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 332 100.00 Very High Very High Very High
Wound Healing 155 100.00 Very High Very High Very High
Cytomegalovirus Infection 1 99.20 Very High Very High Very High
INFLAMMATION 41 97.92 Very High Very High Very High
Cicatrix 9 94.12 High High
Thymoma 14 89.32 High High
Pain 14 86.04 High High
Akathisia 7 84.56 Quite High
Disease 32 75.92 Quite High
Coronary Artery Disease 9 70.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Monounsaturated fatty acid (MUFA) such as oleic acid and polyunsaturated fatty acid (PUFA) such as arachidonic acid affect the function of vessels in several aspects, involved in newly-formed micro-vessels formation and VEGFA expression in the wound healing process [21,22].
Regulation (affect) of Gene_expression (expression) of VEGFA in vessels associated with wound healing
1) Confidence 0.58 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2841600 Disease Relevance 0.83 Pain Relevance 0.09
Since neovascularity, an indicator of immature granulation tissue, diminishes gradually as wound mature [10,20], the extracts did not influence MVD and VEGFA expression at late stage of healing process resulting in an acceleration of wound maturity.
Neg (not) Regulation (influence) of Gene_expression (expression) of VEGFA in granulation associated with injury
2) Confidence 0.50 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2841600 Disease Relevance 1.04 Pain Relevance 0.11
Analysis of VEGFA mRNA expression by RT-PCR
Regulation (Analysis) of Gene_expression (expression) of VEGFA mRNA
3) Confidence 0.42 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2841600 Disease Relevance 0.14 Pain Relevance 0
On day 3, the VEGFA mRNA expression in wounds determined by RT-PCR was seen in all three groups (Fig. 3a).
Regulation (seen) of Gene_expression (expression) of VEGFA mRNA associated with injury
4) Confidence 0.42 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2841600 Disease Relevance 0.35 Pain Relevance 0
Another series of clinical experimentation was based on the delivery of a defective Ad expressing the VEGF121 cDNA under the control of the CMV enhancer/promoter (Ad(GV)VEGF121.10).
Regulation (under) of Gene_expression (expressing) of VEGF associated with cytomegalovirus infection
5) Confidence 0.26 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676804 Disease Relevance 0.30 Pain Relevance 0.05
In present study, the fatty acid extracts of dried Lucilia sericata larvae could up-regulate immunohistochemical, transcriptional and translational level of VEGFA expression and increase the amount of new-formed capillary at inflammatory phase as well as the percent wound contraction at granulation formation phase and scar remolding phase.
Regulation (regulate) of Gene_expression (expression) of VEGFA in granulation associated with cicatrix, inflammation and injury
6) Confidence 0.25 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2841600 Disease Relevance 0.66 Pain Relevance 0.05
Monounsaturated fatty acid (MUFA) such as oleic acid and polyunsaturated fatty acid (PUFA) such as arachidonic acid affect the function of vessels in several aspects, involved in newly-formed micro-vessels formation and VEGFA expression in the wound healing process [21,22].
Regulation (involved) of Gene_expression (expression) of VEGFA in vessels associated with wound healing
7) Confidence 0.25 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2841600 Disease Relevance 0.81 Pain Relevance 0.08
In present study, we utilized fatty acid extracts from dried Lucilia sericata larvae to investigate the effect of the extracts on wound healing, angiogenesis and VEGFA expression in murine wound model.


Spec (investigate) Regulation (effect) of Gene_expression (expression) of VEGFA associated with injury and wound healing
8) Confidence 0.25 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2841600 Disease Relevance 0.60 Pain Relevance 0.03

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