INT26890

Context Info Confidence 0.34 First Reported 1989 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 0.13 Pain Relevance 1.26

nucleoplasm (OGG1) mitochondrion (OGG1) lyase activity (OGG1) hydrolase activity, acting on glycosyl bonds (OGG1) nucleolus (OGG1) nucleus (OGG1)

Anatomy Link Frequency Caco-2 4 OGG1 (Homo sapiens)

Pain Link Frequency Relevance Heat Clonidine 17 99.18 Somatostatin 3 98.16 agonist 1 48.92 ischemia 6 5.00 Inflammation 6 5.00 cINOD 2 5.00 Inflammatory response 2 5.00 alcohol 2 5.00 Crohn's disease 2 5.00

Disease Link Frequency Relevance Heat Stress 40 63.44 Apoptosis 24 39.64 Death 6 33.88 Inflammatory Bowel Disease 14 5.00 Parkinson's Disease 12 5.00 INFLAMMATION 6 5.00 Cv Unclassified Under Development 6 5.00 Disease 6 5.00 Injury 4 5.00 Reperfusion Injury 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, pre-incubation of Caco-2/15 cells with BHT prevented the decline in OGG1 expression.

Negative_regulation (prevented) of Gene_expression (expression) of OGG1 in Caco-2

1) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910735 Disease Relevance 0.06 Pain Relevance 0

However, pre-incubation of Caco-2/15 cells with BHT prevented the decline in OGG1 expression.

Negative_regulation (decline) of Gene_expression (expression) of OGG1 in Caco-2

2) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910735 Disease Relevance 0.06 Pain Relevance 0

In somatostatin (SRIF) antiserum (anti-SRIF; 0.5 ml, iv)-treated adult diestrous animals, CLON induced a significant GH surge that was suppressed by oGH preinjection.

Negative_regulation (suppressed) of Gene_expression (preinjection) of oGH associated with somatostatin and clonidine

3) Confidence 0.12 Published 1989 Journal Endocrinology Section Abstract Doc Link 2571494 Disease Relevance 0 Pain Relevance 1.26

General Comments

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