INT268903
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
This knowledge can be used to adjust degradation of SLN and consequently drug release in a controlled way (Olbrich and Muller 1999). | |||||||||||||||
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The longer the ethylene oxide chains are in the molecule, the more hindered is the anchoring of the lipase/co-lipase complex and consequently the degradation of the SLN. | |||||||||||||||
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SLN show different degradation rates by the lipolytic enzyme pancreatic lipase as a function of their composition (lipid matrix, stabilizing surfactant) and it has been demonstrated that the longer the fatty acid chains of the acylglycerols are, the slower is their degradation (Olbrich and Muller 1999). | |||||||||||||||
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The additional advantage of the SLN are the large scale production, protection of the drug against chemical degradation, ease of modulation of the drug release profile and high drug pay load3. | |||||||||||||||
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Afterwards, it can be postulated that SLN undergo physiological degradation and the insulin enter into the blood circulation. | |||||||||||||||
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General Comments
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