INT268912

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.22
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 2
neurons 2
TRGV9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 16 99.80 Very High Very High Very High
Hyperalgesia 1 96.88 Very High Very High Very High
Hippocampus 58 66.24 Quite High
imagery 5 51.44 Quite High
nMDA receptor 23 50.00 Quite Low
nMDA receptor antagonist 21 5.00 Very Low Very Low Very Low
amygdala 13 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
depression 5 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 7 98.08 Very High Very High Very High
Anxiety Disorder 105 97.52 Very High Very High Very High
Hyperalgesia 1 96.88 Very High Very High Very High
Shock 6 73.08 Quite High
Cognitive Disorder 7 50.00 Quite Low
Ganglion Cysts 1 43.84 Quite Low
Scotoma 5 39.64 Quite Low
Depression 5 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It remains to be seen however whether Pulvinar input is capable of activating area V2, V3 neurons in the absence of V1 input.
Spec (whether) Positive_regulation (activating) of Gene_expression (neurons) of V2 in neurons
1) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0
V2 also produced a larger response to the moderately painful stimulus in terms of pain ratings (anxiety-induced hyperalgesia), and increased neuronal activity in an area of the parahippocampal gyrus, corresponding to the entorhinal cortex.
Positive_regulation (response) of Gene_expression (produced) of V2 in neuronal associated with pain, hyperalgesia and anxiety disorder
2) Confidence 0.05 Published 2010 Journal European Journal of Pharmacology Section Body Doc Link PMC2824088 Disease Relevance 1.22 Pain Relevance 0.80

General Comments

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