INT269029

Context Info Confidence 0.42 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 2.06 Pain Relevance 0.03

transport (Cybb) mitochondrion (Cybb) oxidoreductase activity (Cybb) Golgi apparatus (Cybb) endoplasmic reticulum (Cybb) plasma membrane (Cybb)

Anatomy Link Frequency neurons 1 brain 1 Cybb (Mus musculus)

Pain Link Frequency Relevance Heat cva 6 59.72 GABAergic 9 50.00 Hippocampus 13 37.64 cytokine 13 24.36 Inflammation 12 5.00 anesthesia 7 5.00 imagery 6 5.00 interneuron 5 5.00 ketamine 4 5.00 long-term potentiation 3 5.00

Disease Link Frequency Relevance Heat Brain Injury 106 99.96 Contusions 10 98.40 Stress 9 95.28 Aging 23 76.88 Death 10 70.20 Cv General 4 Under Development 4 59.72 Targeted Disruption 4 57.36 Cognitive Disorder 35 50.00 Pressure And Volume Under Development 2 44.20 Hemorrhage 2 43.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results suggest that in neurons and at the synapse, Nox2 is in the assembled, superoxide-capable form, and is responsible for a sustained increase in neuronal and synaptic superoxide production in the aged brain.

Regulation (synapse) of Nox2 in neurons

1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.08 Pain Relevance 0

Two days after TBI, gp91phox immunoreactivity was dramatically increased in the peri-contusion region.

Regulation (immunoreactivity) of gp91phox associated with contusions and brain injury

2) Confidence 0.26 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2917406 Disease Relevance 0.90 Pain Relevance 0

As ROS derived from gp91phox play an important role in primary and secondary brain damage after TBI, modulation of gp91phox in classically activated microglia and gp91phox-derived ROS may provide a new therapeutic strategy in combating post-traumatic brain injury.

Regulation (modulation) of gp91phox in brain associated with brain injury

3) Confidence 0.26 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2917406 Disease Relevance 1.08 Pain Relevance 0.03

General Comments

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