INT269029

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.06
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cybb) mitochondrion (Cybb) oxidoreductase activity (Cybb)
Golgi apparatus (Cybb) endoplasmic reticulum (Cybb) plasma membrane (Cybb)
Anatomy Link Frequency
neurons 1
brain 1
Cybb (Mus musculus)
Pain Link Frequency Relevance Heat
cva 6 59.72 Quite High
GABAergic 9 50.00 Quite Low
Hippocampus 13 37.64 Quite Low
cytokine 13 24.36 Low Low
Inflammation 12 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
interneuron 5 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
long-term potentiation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Brain Injury 106 99.96 Very High Very High Very High
Contusions 10 98.40 Very High Very High Very High
Stress 9 95.28 Very High Very High Very High
Aging 23 76.88 Quite High
Death 10 70.20 Quite High
Cv General 4 Under Development 4 59.72 Quite High
Targeted Disruption 4 57.36 Quite High
Cognitive Disorder 35 50.00 Quite Low
Pressure And Volume Under Development 2 44.20 Quite Low
Hemorrhage 2 43.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that in neurons and at the synapse, Nox2 is in the assembled, superoxide-capable form, and is responsible for a sustained increase in neuronal and synaptic superoxide production in the aged brain.
Regulation (synapse) of Nox2 in neurons
1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.08 Pain Relevance 0
Two days after TBI, gp91phox immunoreactivity was dramatically increased in the peri-contusion region.


Regulation (immunoreactivity) of gp91phox associated with contusions and brain injury
2) Confidence 0.26 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2917406 Disease Relevance 0.90 Pain Relevance 0
As ROS derived from gp91phox play an important role in primary and secondary brain damage after TBI, modulation of gp91phox in classically activated microglia and gp91phox-derived ROS may provide a new therapeutic strategy in combating post-traumatic brain injury.


Regulation (modulation) of gp91phox in brain associated with brain injury
3) Confidence 0.26 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2917406 Disease Relevance 1.08 Pain Relevance 0.03

General Comments

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