INT269033

Context Info Confidence 0.42 First Reported 2009 Last Reported 2009 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.29 Pain Relevance 0.18

transport (Cybb) mitochondrion (Cybb) oxidoreductase activity (Cybb) Golgi apparatus (Cybb) endoplasmic reticulum (Cybb) plasma membrane (Cybb)

Anatomy Link Frequency brain 2 Cybb (Mus musculus)

Pain Link Frequency Relevance Heat Hippocampus 13 83.92 GABAergic 9 72.44 ketamine 4 67.96 nMDA receptor 1 65.60 cytokine 9 5.00 Inflammation 6 5.00 imagery 6 5.00 interneuron 5 5.00 long-term potentiation 3 5.00 anesthesia 3 5.00

Disease Link Frequency Relevance Heat Aging 23 96.56 Urological Neuroanatomy 2 60.92 Cognitive Disorder 35 52.00 INFLAMMATION 6 5.00 Disease 6 5.00 Hypertension 2 5.00 Schizophrenia 2 5.00 Diabetes Mellitus 2 5.00 Frailty 2 5.00 Cancer 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To determine whether old mice lacking IL-6, which had lower Nox2 expression and superoxide production in brain would have preservation of PV-interneurons during aging, we carried out analysis in young and old wild-type and IL-6-/- mice.

Spec (whether) Regulation (had) of Gene_expression (expression) of Nox2 in brain associated with aging

1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.29 Pain Relevance 0.18

General Comments

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