INT269035

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Context Info
Confidence 0.61
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.61
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion organization (Nrf1) nucleus (Nrf1) DNA binding (Nrf1)
cytoplasm (Nrf1)
Anatomy Link Frequency
cortex 3
hippocampus 1
Nrf1 (Mus musculus)
Pain Link Frequency Relevance Heat
electroacupuncture 164 99.16 Very High Very High Very High
Hippocampus 26 98.92 Very High Very High Very High
cytokine 18 91.36 High High
ischemia 2 65.60 Quite High
GABAergic 18 50.00 Quite Low
interneuron 10 33.64 Quite Low
Eae 2 15.48 Low Low
Acupuncture 20 9.28 Low Low
Inflammation 14 5.00 Very Low Very Low Very Low
tolerance 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 4 94.60 High High
Aging 48 92.24 High High
Hyperglycemia 6 90.00 High High
Cognitive Disorder 70 83.52 Quite High
Diabetes Mellitus 32 81.12 Quite High
Stress 6 80.64 Quite High
Disease 18 76.84 Quite High
Stroke 4 68.12 Quite High
Psychosis 2 67.80 Quite High
Delirium 2 67.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
is a coactivator for NRF1 expression [24], discrepancy between induced PGC-1?
Positive_regulation (coactivator) of Gene_expression (expression) of NRF1
1) Confidence 0.61 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.35 Pain Relevance 0.19
The resultant increase in expression of mitochondrial genes, including NRF1, may exert positive effects on insulin signaling [12] (Figure 4).
Positive_regulation (increase) of Gene_expression (expression) of NRF1
2) Confidence 0.61 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.44 Pain Relevance 0.26
We found that expression of Nox2, the respiratory burst oxidase, was significantly increased in neurons throughout the hippocampus and cortex in aged mouse brain, as documented by immunocytochemistry, Western blot analysis, and mRNA (data not shown).
Positive_regulation (increased) of Gene_expression (expression) of respiratory burst oxidase in cortex associated with hippocampus
3) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 1.41 Pain Relevance 0.17
We found that expression of Nox2, the respiratory burst oxidase, was significantly increased in neurons throughout the hippocampus and cortex in aged mouse brain, as documented by immunocytochemistry, Western blot analysis, and mRNA (data not shown).
Positive_regulation (increased) of in hippocampus Gene_expression (expression) of respiratory burst oxidase in cortex associated with hippocampus
4) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 1.41 Pain Relevance 0.17

General Comments

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