INT269036

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.63
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cybb) mitochondrion (Cybb) oxidoreductase activity (Cybb)
Golgi apparatus (Cybb) endoplasmic reticulum (Cybb) plasma membrane (Cybb)
Cybb (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 26 74.36 Quite High
imagery 12 64.00 Quite High
cytokine 20 61.08 Quite High
GABAergic 18 50.00 Quite Low
ischemia 2 35.32 Quite Low
Inflammation 13 5.00 Very Low Very Low Very Low
interneuron 10 5.00 Very Low Very Low Very Low
ketamine 8 5.00 Very Low Very Low Very Low
long-term potentiation 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 129 95.00 High High
Infection 68 85.84 High High
Mycobacterial Infection 141 69.20 Quite High
Aging 46 61.96 Quite High
Cognitive Disorder 70 53.24 Quite High
Disease 12 46.56 Quite Low
Schizophrenia 4 45.20 Quite Low
Stroke 4 37.84 Quite Low
Psychosis 2 37.52 Quite Low
Delirium 2 37.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A substantial increase in Nox2 protein was observed in extracts prepared from old wild-type mice, which was absent in similar age IL-6-deficient animals (Fig. 1d, e).


Negative_regulation (absent) of Positive_regulation (increase) of Nox2 protein
1) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.06 Pain Relevance 0.07
Moreover, two chemically distinct Nox inhibitors, apocynin and AEBSF, fully blocked the age-related increase in Nox2 activity (O2 consumption) in synaptosomes prepared from old animals, and apocynin reduced synaptosomal superoxide production to levels in young synaptosomes, as well.
Negative_regulation (blocked) of Positive_regulation (increase) of Nox2
2) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.12 Pain Relevance 0.10
The results presented in the current manuscript enable us to formulate the following hypothesis: successful intracellular pathogens need strategies to inhibit prolonged activation of NOX2 and/or neutralize the generated superoxides since this will otherwise be sensed by the host cell and will lead to host cell apoptosis.
Negative_regulation (inhibit) of Positive_regulation (activation) of NOX2 associated with apoptosis
3) Confidence 0.13 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858756 Disease Relevance 0.46 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox