INT269037

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.35
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.95
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cybb) mitochondrion (Cybb) oxidoreductase activity (Cybb)
Golgi apparatus (Cybb) endoplasmic reticulum (Cybb) plasma membrane (Cybb)
Anatomy Link Frequency
microglia 1
Cybb (Mus musculus)
Pain Link Frequency Relevance Heat
dopaminergic neurodegeneration 5 82.40 Quite High
Substantia nigra 37 65.12 Quite High
midbrain 3 62.72 Quite High
Dopamine 6 56.96 Quite High
Hippocampus 26 56.40 Quite High
GABAergic 18 50.00 Quite Low
cytokine 30 43.12 Quite Low
ischemia 2 17.36 Low Low
Inflammatory mediators 1 17.16 Low Low
Inflammation 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mycobacterial Infection 423 94.96 High High
Apoptosis 387 94.00 High High
Injury 4 76.96 Quite High
Suicidal Behaviour 6 75.16 Quite High
Sprains And Strains 15 69.76 Quite High
Aging 46 65.28 Quite High
Cognitive Disorder 70 50.00 Quite Low
Neutrophil Disorders 9 42.56 Quite Low
Ulcers 6 38.96 Quite Low
Disease 41 28.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nox2 was also found to be constitutively active in synaptosomes; Nox2-dependent O2 consumption and superoxide production in synaptosomes was detected immediately after addition of the substrate, NADPH, and in contrast to a number of other studies which have required agents, such as phorbol esters, to induce assembly of the Nox2 complex, required no other additions to observe O2 consumption and superoxide generation.
Nox2 Binding (active) of
1) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0 Pain Relevance 0.03
Nox2 was also found to be constitutively active in synaptosomes; Nox2-dependent O2 consumption and superoxide production in synaptosomes was detected immediately after addition of the substrate, NADPH, and in contrast to a number of other studies which have required agents, such as phorbol esters, to induce assembly of the Nox2 complex, required no other additions to observe O2 consumption and superoxide generation.
Nox2 Binding (complex) of
2) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.07 Pain Relevance 0
Interestingly, the katG mutant has been described as being attenuated and the attenuation was dependent on the presence of functional NOX2 complex in the host[55].
NOX2 Binding (complex) of
3) Confidence 0.12 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858756 Disease Relevance 0.99 Pain Relevance 0
Additionally, the cytosolic GTPase Rac has to be recruited in order to form a fully active NOX2 complex [1].
NOX2 Binding (complex) of
4) Confidence 0.11 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858756 Disease Relevance 0.08 Pain Relevance 0
It will be interesting to know if this mechanism can be extended to other pathogens such as Leishmania donovani, which is able to inhibit host cell NOX2 recruitment to the phagosome.
NOX2 Binding (recruitment) of
5) Confidence 0.10 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858756 Disease Relevance 0.74 Pain Relevance 0
There was a trend towards increased gp91PHOX positive microglia in both wild-type mice and Fc?
gp91PHOX Binding (microglia) of in microglia
6) Confidence 0.07 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.08 Pain Relevance 0.13

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox