INT269042

Context Info Confidence 0.47 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.15 Pain Relevance 0.13

transport (Cybb) mitochondrion (Cybb) oxidoreductase activity (Cybb) Golgi apparatus (Cybb) endoplasmic reticulum (Cybb) plasma membrane (Cybb)

Anatomy Link Frequency microglia 2 Cybb (Mus musculus)

Pain Link Frequency Relevance Heat dopaminergic neurodegeneration 5 82.40 Substantia nigra 37 65.52 midbrain 3 62.72 Dopamine 6 56.96 GABAergic 9 50.00 Hippocampus 13 44.32 cytokine 17 31.04 Inflammatory mediators 1 17.56 ischemia 1 5.28 Inflammation 16 5.00

Disease Link Frequency Relevance Heat Mycobacterial Infection 141 94.96 Apoptosis 129 93.28 Injury 3 77.36 Aging 23 65.28 Cognitive Disorder 35 50.00 Ulcers 2 40.56 Sprains And Strains 5 36.48 Adhesions 2 20.16 INFLAMMATION 19 17.16 Infection 67 16.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Nox2 was also found to be constitutively active in synaptosomes; Nox2-dependent O2 consumption and superoxide production in synaptosomes was detected immediately after addition of the substrate, NADPH, and in contrast to a number of other studies which have required agents, such as phorbol esters, to induce assembly of the Nox2 complex, required no other additions to observe O2 consumption and superoxide generation.

Positive_regulation (induce) of Nox2 Binding (complex) of

1) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.07 Pain Relevance 0

Interestingly, the katG mutant has been described as being attenuated and the attenuation was dependent on the presence of functional NOX2 complex in the host[55].

Positive_regulation (dependent) of NOX2 Binding (complex) of

2) Confidence 0.16 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858756 Disease Relevance 1.01 Pain Relevance 0

There was a trend towards increased gp91PHOX positive microglia in both wild-type mice and Fc?

Positive_regulation (increased) of gp91PHOX Binding (microglia) of in microglia

3) Confidence 0.09 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2975641 Disease Relevance 0.08 Pain Relevance 0.13

General Comments

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