INT269060

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Context Info
Confidence 0.75
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.65
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cybb) mitochondrion (Cybb) Golgi apparatus (Cybb)
endoplasmic reticulum (Cybb) intracellular (Cybb) cytoplasm (Cybb)
Anatomy Link Frequency
neurons 1
interneurons 1
Il6 (Mus musculus)
Cybb (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 12 97.72 Very High Very High Very High
interneuron 10 97.08 Very High Very High Very High
cytokine 18 76.48 Quite High
Hippocampus 26 75.72 Quite High
ketamine 8 63.68 Quite High
imagery 12 51.00 Quite High
GABAergic 18 50.00 Quite Low
long-term potentiation 6 34.00 Quite Low
anesthesia 6 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 12 97.72 Very High Very High Very High
Aging 46 94.96 High High
Stress 2 73.72 Quite High
Cognitive Disorder 70 59.84 Quite High
Cancer 4 32.40 Quite Low
Disease 12 5.00 Very Low Very Low Very Low
Hypertension 4 5.00 Very Low Very Low Very Low
Schizophrenia 4 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 4 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of Nox2 by IL-6 in neurons was dependent on NF?
IL-6 Positive_regulation (Induction) of Nox2 in neurons
1) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.30 Pain Relevance 0.14
In addition, as predicted by our results showing that injected IL-6 induces brain Nox2, and that IL-6-/- mice lack induction of Nox2, there was preservation of these interneurons in aged IL-6-/- mice which was highly significant for CA3, and approached significance for CA1.
IL-6 Positive_regulation (induces) of Nox2 in interneurons
2) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.35 Pain Relevance 0.12

General Comments

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