INT269060

Context Info Confidence 0.75 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.65 Pain Relevance 0.26

transport (Cybb) mitochondrion (Cybb) Golgi apparatus (Cybb) endoplasmic reticulum (Cybb) intracellular (Cybb) cytoplasm (Cybb)

Anatomy Link Frequency neurons 1 interneurons 1 Il6 (Mus musculus) Cybb (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 12 97.72 interneuron 10 97.08 cytokine 18 76.48 Hippocampus 26 75.72 ketamine 8 63.68 imagery 12 51.00 GABAergic 18 50.00 long-term potentiation 6 34.00 anesthesia 6 5.00 Central nervous system 2 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 12 97.72 Aging 46 94.96 Stress 2 73.72 Cognitive Disorder 70 59.84 Cancer 4 32.40 Disease 12 5.00 Hypertension 4 5.00 Schizophrenia 4 5.00 Urological Neuroanatomy 4 5.00 Diabetes Mellitus 4 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Induction of Nox2 by IL-6 in neurons was dependent on NF?

IL-6 Positive_regulation (Induction) of Nox2 in neurons

1) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.30 Pain Relevance 0.14

In addition, as predicted by our results showing that injected IL-6 induces brain Nox2, and that IL-6-/- mice lack induction of Nox2, there was preservation of these interneurons in aged IL-6-/- mice which was highly significant for CA3, and approached significance for CA1.

IL-6 Positive_regulation (induces) of Nox2 in interneurons

2) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.35 Pain Relevance 0.12

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