INT269061

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Context Info
Confidence 0.04
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.59
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6, Il6ra) extracellular region (Il6, Il6ra) enzyme binding (Il6ra)
Il6 (Mus musculus)
Il6ra (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 22 98.64 Very High Very High Very High
Inflammation 40 94.60 High High
Central nervous system 1 84.76 Quite High
rheumatoid arthritis 1 75.00 Quite High
GABAergic 9 50.00 Quite Low
ketamine 4 10.08 Low Low
Hippocampus 13 5.00 Very Low Very Low Very Low
imagery 11 5.00 Very Low Very Low Very Low
interneuron 5 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 4 98.52 Very High Very High Very High
Disease 24 98.12 Very High Very High Very High
Acute-phase Reaction 1 96.60 Very High Very High Very High
Cervical Cancer 2 94.76 High High
INFLAMMATION 41 94.60 High High
Cancer 82 88.48 High High
Rheumatoid Arthritis 61 87.20 High High
Osteoporosis 9 85.36 High High
Fatigue 10 84.68 Quite High
Anaemia 9 84.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Canonical IL-6 signaling involves binding of IL-6 to its cognate receptor (IL-6R)[11] to cause dimerization of two gp130 proteins, which in turn activate intracellular signaling and transcriptional regulation through the Jak/STAT (janus kinase/signal transducers and activators of transcription) pathway, and the transcription factor SOCS3 (suppressor of cytokine signaling-3).
IL-6 Binding (binding) of IL-6R associated with cytokine
1) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.74 Pain Relevance 0.23
Indeed, trans-signalling, where IL-6 binds to the sIL-6R, homodimerizes with glycoprotein 130 subunits and induces signal transduction, has been found to play a key role in acute and chronic inflammation.
IL-6 Binding (binds) of sIL-6R associated with inflammation
2) Confidence 0.03 Published 2010 Journal Rheumatology (Oxford, England) Section Abstract Doc Link PMC2789585 Disease Relevance 1.00 Pain Relevance 0.22
These observations highlighted the potential use of a small peptide, which blocks IL-6/IL-6R interaction, in the management of patients with malignant disease.


IL-6 Binding (interaction) of IL-6R associated with malignant neoplastic disease and disease
3) Confidence 0.02 Published 2006 Journal Int J Pept Res Ther Section Body Doc Link PMC2678933 Disease Relevance 0.85 Pain Relevance 0

General Comments

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