INT269067

Context Info Confidence 0.17 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

plasma membrane (Nox4, Ncf1) mitochondrion (Nox4) cell morphogenesis (Nox4) Golgi apparatus (Ncf1) endoplasmic reticulum (Nox4) cytoplasm (Ncf1)

Nox4 (Mus musculus) Ncf1 (Mus musculus)

Pain Link Frequency Relevance Heat GABAergic 9 50.00 Hippocampus 13 5.00 cytokine 9 5.00 Inflammation 6 5.00 imagery 6 5.00 interneuron 5 5.00 ketamine 4 5.00 long-term potentiation 3 5.00 anesthesia 3 5.00 Central nervous system 1 5.00

Disease Link Frequency Relevance Heat Cognitive Disorder 35 50.00 Aging 23 21.28 INFLAMMATION 6 5.00 Disease 6 5.00 Hypertension 2 5.00 Schizophrenia 2 5.00 Urological Neuroanatomy 2 5.00 Diabetes Mellitus 2 5.00 Frailty 2 5.00 Cancer 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Since apocynin and AEBSF block translocation and binding of p47phox to the Nox-p22phox complex, Nox4 is insensitive to these inhibitors, as previously reported[30]–[32].

Nox4 Negative_regulation (block) of Localization (translocation) of p47phox

1) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0 Pain Relevance 0

General Comments

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