INT269068

Context Info Confidence 0.49 First Reported 2009 Last Reported 2009 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.06 Pain Relevance 0

transport (Cybb) mitochondrion (Cybb) Golgi apparatus (Cybb) endoplasmic reticulum (Cybb) intracellular (Cybb) cytoplasm (Cybb)

Anatomy Link Frequency neuronal 2 Il6 (Mus musculus) Cybb (Mus musculus)

Pain Link Frequency Relevance Heat GABAergic 9 50.00 imagery 6 44.56 Hippocampus 13 5.00 cytokine 9 5.00 Inflammation 6 5.00 interneuron 5 5.00 ketamine 4 5.00 long-term potentiation 3 5.00 anesthesia 3 5.00 Central nervous system 1 5.00

Disease Link Frequency Relevance Heat Aging 23 59.72 Cognitive Disorder 35 50.00 INFLAMMATION 6 5.00 Disease 6 5.00 Hypertension 2 5.00 Schizophrenia 2 5.00 Urological Neuroanatomy 2 5.00 Diabetes Mellitus 2 5.00 Frailty 2 5.00 Cancer 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The role of IL-6 in mediating age-related induction of neuronal Nox2 was then examined in old IL-6-/- mice, and in wild-type mice treated directly with IL-6.

IL-6 Spec (examined) Regulation (role) of Positive_regulation (induction) of Nox2 in neuronal

1) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.06 Pain Relevance 0

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