INT269071

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Context Info
Confidence 0.40
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.73
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6, Il6) extracellular region (IL6, Il6) aging (IL6)
Anatomy Link Frequency
cleavage 1
IL6 (Homo sapiens)
Il6 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 9 94.80 High High
Inflammation 6 76.08 Quite High
Central nervous system 1 66.40 Quite High
GABAergic 9 50.00 Quite Low
ketamine 4 45.20 Quite Low
Hippocampus 13 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
interneuron 5 5.00 Very Low Very Low Very Low
long-term potentiation 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 1 78.48 Quite High
Acute-phase Reaction 1 78.24 Quite High
INFLAMMATION 6 76.08 Quite High
Infection 1 74.00 Quite High
Confusion 1 71.20 Quite High
Cognitive Disorder 35 70.00 Quite High
Dementia 1 58.64 Quite High
Stroke 2 58.12 Quite High
Schizophrenia 2 51.92 Quite High
Aging 23 42.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An alternative signaling pathway involves cleavage of the full-length membrane-bound IL-6R to produce the soluble sIL-6R, which binds to IL-6 and can then activate gp130 signaling directly, even in cells lacking membrane IL-6 receptors(reviewed in [2]).
IL-6 Binding (binds) of IL-6 in cleavage
1) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.73 Pain Relevance 0.19

General Comments

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