INT269103

Context Info Confidence 0.26 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.97 Pain Relevance 0.46

cytoplasm (AOX1)

AOX1 (Homo sapiens)

Pain Link Frequency Relevance Heat alcohol 93 92.68 bradykinin 1 90.40 depression 3 59.76 Inflammation 1 58.72 cytokine 1 57.68 abdominal pain 1 55.88 backache 5 52.80 nud 2 51.80 Angina 3 48.64 imagery 4 5.00

Disease Link Frequency Relevance Heat Hyperlipidemia 2 97.48 Marfan Syndrome 43 95.36 Increased Venous Pressure Under Development 5 95.16 Stress 10 94.08 Hypertension 11 93.00 Apoptosis 3 85.20 Recurrence 4 70.56 Aortic Valve Insufficiency 3 62.88 Cv General 2 Under Development 1 61.76 Mitral Valve Prolapse 2 60.84

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Three patients demonstrated no relevant risk factors for the development of AoD.

Gene_expression (development) of AoD

1) Confidence 0.26 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2678699 Disease Relevance 1.16 Pain Relevance 0.19

As the major metabolite of ethanol, acetaldehyde production results directly in the formation of free radicals through aldehyde oxidase and xanthine oxidase-associated oxidation and indirectly in decreased antioxidant defenses (e.g., GSH levels) [34,104,105], resulting in oxidative stress.

Gene_expression (production) of aldehyde oxidase associated with stress

2) Confidence 0.09 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872347 Disease Relevance 0.81 Pain Relevance 0.28

General Comments

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