INT269141

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Context Info
Confidence 0.20
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 0
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Oas1a) nucleus (Oas1a) nucleotidyltransferase activity (Oas1a)
Anatomy Link Frequency
neurons 2
spinal cord 1
Oas1a (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 5 99.56 Very High Very High Very High
Somatosensory cortex 336 98.04 Very High Very High Very High
wide dynamic range 3 96.96 Very High Very High Very High
Mono iodoacetate 57 92.96 High High
Dorsal horn 13 91.84 High High
c fibre 18 87.52 High High
Glutamate 56 82.52 Quite High
primary somatosensory cortex 24 76.32 Quite High
Action potential 99 73.32 Quite High
withdrawal 15 59.44 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 55 50.00 Quite Low
Neuropathic Pain 29 50.00 Quite Low
Hypersensitivity 30 37.52 Quite Low
Camurati-engelmann Disease 1 6.32 Low Low
Pain 47 5.00 Very Low Very Low Very Low
INFLAMMATION 14 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Nociception 7 5.00 Very Low Very Low Very Low
Nervous System Injury 5 5.00 Very Low Very Low Very Low
Hyperalgesia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Animals were anaesthetised using urethane (240 mg/Kg), and a laminectomy was performed exposing L3-L5 of the spinal cord.
Gene_expression (exposing) of L3 in spinal cord associated with spinal cord
1) Confidence 0.20 Published 2009 Journal Mol Pain Section Body Doc Link PMC2678995 Disease Relevance 0 Pain Relevance 0.50
L3) was present but was not the strongest projection.
Gene_expression (present) of L3
2) Confidence 0.06 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.17
The division between L2 and L3 in vS1 was drawn between groups of neurons that did not receive appreciable L4 input (L2 [58]) and those that did.
Gene_expression (division) of L3 in neurons
3) Confidence 0.06 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.12
However, ascending pathways were not unique to vS1, as a similar but weaker L3/5A?
Gene_expression (/) of L3
4) Confidence 0.05 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.17
L2/3 pathway and descending L3?
Gene_expression (descending) of L3
5) Confidence 0.05 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.09
neuron basis, the L3?
Gene_expression (basis) of L3 in neuron
6) Confidence 0.05 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.04
Another prominent projection was from L2 and L3 to L5A and L5B; inputs originating in more superficial regions of L2/3 targeted relatively more superficial regions of L5A/L5B (note the diagonal shape of the L2/3?
Gene_expression (was) of L3
7) Confidence 0.05 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.03
The upward compression of layers in vM1, typical of cortical convexities [28], may be why L3/5A?
Gene_expression (/) of L3
8) Confidence 0.05 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.16
L3 projection, and local input to L6 was prominent.
Gene_expression (projection) of L3
9) Confidence 0.05 Published 2011 Journal PLoS Biology Section Abstract Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.21

General Comments

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