INT26918

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Context Info
Confidence 0.27
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 2.31
Pain Relevance 2.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ITPR3) small molecule metabolic process (ITPR3) endoplasmic reticulum (ITPR3)
transmembrane transport (ITPR3) cytoplasm (ITPR3) signal transduction (ITPR3)
Anatomy Link Frequency
hemocytes 2
ITPR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 30 99.66 Very High Very High Very High
agonist 281 98.20 Very High Very High Very High
bradykinin 135 95.24 Very High Very High Very High
Kinase C 32 93.84 High High
Calcium channel 18 92.80 High High
Clonidine 4 91.16 High High
headache 3 89.76 High High
Inflammation 19 88.24 High High
adenocard 14 65.48 Quite High
Catecholamine 1 61.88 Quite High
Disease Link Frequency Relevance Heat
Vomiting 3 90.40 High High
Headache 3 89.76 High High
Diuresis 3 88.64 High High
INFLAMMATION 22 88.24 High High
Increased Venous Pressure Under Development 20 87.56 High High
Pathologic Processes 4 86.64 High High
Convulsion 5 78.00 Quite High
Overdose 3 76.56 Quite High
Cancer 8 76.16 Quite High
Leiomyosarcoma 1 74.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this metabotropic model, PLC activation would lead to the production of IP3, which in turn would activate the IP3 receptor causing release of Ca2+ from the ER [15].
Positive_regulation (activate) of Gene_expression (production) of IP3
1) Confidence 0.27 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0.09 Pain Relevance 0.08
The octopamine-treated hemocytes were shown to increase IP3 production in the latter stage of phagocytosis.
Positive_regulation (increase) of Gene_expression (production) of IP3 in hemocytes
2) Confidence 0.27 Published 1994 Journal Arch. Insect Biochem. Physiol. Section Abstract Doc Link 8068962 Disease Relevance 0 Pain Relevance 0.25
Second, propofol reduces the production of IP3 and calcium release from intracellular stores (16, 17), but aminophylline induced Ca2+ release from intracellular stores, occurs via increased production of IP3 through G-protein-mediated activation (21, 25).
Positive_regulation (occurs) of Gene_expression (production) of IP3
3) Confidence 0.24 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2908795 Disease Relevance 0.81 Pain Relevance 0.31
Octopamine enhanced IP3 production with a maximal peak at 100 nM.
Positive_regulation (enhanced) of Gene_expression (production) of IP3
4) Confidence 0.18 Published 1994 Journal Arch. Insect Biochem. Physiol. Section Abstract Doc Link 8068962 Disease Relevance 0 Pain Relevance 0.08
Similarly, 5-HT enhanced IP3 production with a maximal effect at 10 nM.
Positive_regulation (enhanced) of Gene_expression (production) of IP3
5) Confidence 0.18 Published 1994 Journal Arch. Insect Biochem. Physiol. Section Abstract Doc Link 8068962 Disease Relevance 0 Pain Relevance 0.08
Second, propofol reduces the production of IP3 and calcium release from intracellular stores (16, 17), but aminophylline induced Ca2+ release from intracellular stores, occurs via increased production of IP3 through G-protein-mediated activation (21, 25).
Positive_regulation (increased) of Gene_expression (production) of IP3
6) Confidence 0.16 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2908795 Disease Relevance 0.80 Pain Relevance 0.31
In contrast, NE in the presence of yohimbine (an alpha-2 antagonist) or propranolol stimulated IP3 production to levels comparable to that stimulated by NE alone.
Positive_regulation (stimulated) of Gene_expression (production) of IP3 associated with antagonist
7) Confidence 0.16 Published 1989 Journal Biol. Reprod. Section Abstract Doc Link 2572279 Disease Relevance 0.07 Pain Relevance 0.34
This action is transduced by the production of inositol triphosphate (IP3) through the G-protein-mediated activation of phospholipase C (12).
Positive_regulation (transduced) of Gene_expression (production) of IP3
8) Confidence 0.15 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2908795 Disease Relevance 0.07 Pain Relevance 0
, leading to production of IP3 and release of intracellular calcium [19,20].
Positive_regulation (leading) of Gene_expression (production) of IP3
9) Confidence 0.05 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0.47 Pain Relevance 0.34
PI3K has been found to mediate phosphorylation and translocation of phospholipase C-gamma and resultant IP3 production in response to activation of P2Y purinergic receptors - this could be one mechanism by which PI3 kinase inhibitors inhibit both the initial response to ATP and the resensitization of P2Y purinergic receptors [38].
Positive_regulation (resultant) of Gene_expression (production) of IP3
10) Confidence 0.04 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2955562 Disease Relevance 0 Pain Relevance 0.34
S239,331A with U46619 yielded efficient increases in [Ca2+]i mobilization and IP3 generation (Fig. 6A and data not shown), the level of its agonist-induced desensitization was not significantly different to that of TP?
Positive_regulation (increases) of Gene_expression (generation) of IP3 associated with agonist
11) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.09
T337,340A with U46619 yielded efficient increases in [Ca2+]i mobilization (Fig. 6C and E, respectively) and IP3 generation (data not shown), in each case the level of agonist-induced desensitization was not significantly different to that of their respective single mutants TP?
Positive_regulation (increases) of Gene_expression (generation) of IP3 associated with agonist
12) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.08
activation leading to increases in IP3 generation and mobilization of [Ca2+]i.
Positive_regulation (increases) of Gene_expression (generation) of IP3
13) Confidence 0.04 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.12
Exact mechanisms linking PIP3 formation to Ca2+ signals are not yet known, but PIP3 may activate a PLC isoform triggering InsP3 production [118].
Positive_regulation (triggering) of Gene_expression (production) of InsP3
14) Confidence 0.03 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0

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